Evidence map›Paper›PMID 36864252›Full record

ArticleNature medicine2023

A deep-learning algorithm to classify skin lesions from mpox virus infection.

Alexander H Thieme, Yuanning Zheng, Gautam Machiraju, Chris Sadee, Mirja Mittermaier, Maximilian Gertler, Jorge L Salinas, Krithika Srinivasan, Prashnna Gyawali, Francisco Carrillo-Perez and 15 more

Open access · hybridFull text read
In one paragraph

Article in Nature medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Demographic Reporting and the Absence of Hispanic/Latino Representation in Dermatology Artificial Intelligence: A Scoping Review.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Article
  3. Mpox and the one health approach.Dialogues in health · 2026
    Review
  4. Review
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  11. Article
  12. DEEP AUTOMATIC ALIGNMENT OF MPOX DERMATOLOGICAL HAND PHOTOGRAPHY.Proceedings. IEEE International Symposium on Biomedical Imaging · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 14 institutions in 5 countries.

Alexander H ThiemeDepartment of Medicine, Stanford University, Stanford, CA, USA. thieme@stanford.edu.ORCID http://orcid.org/0000-0002-4564-3347
Yuanning ZhengDepartment of Medicine, Stanford University, Stanford, CA, USA.
Gautam MachirajuDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4743-0123
Chris SadeeDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7416-1470
Mirja MittermaierBerlin Institute of Health at Charité-Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Digital Clinician Scientist Program, Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-0678-6676
Maximilian GertlerInstitute of Tropical Medicine and International Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-6384-9162
Jorge L SalinasDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
Krithika SrinivasanDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
Prashnna GyawaliDepartment of Medicine, Stanford University, Stanford, CA, USA.
Francisco Carrillo-PerezDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0974-4092
Angelo CapodiciDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7505-0702
Maximilian UhligDepartment of Medicine, Justus-Liebig-Universität Gießen, Gießen, Germany.
Daniel HabenichtTechnical University Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-7864-121X
Anastassia LöserDepartment of Radiotherapy, University Medical Center Schleswig-Holstein, Lübeck, Germany.
Maja KohlerHeidelberg Institute of Global Health, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6633-6875
Maximilian SchuesslerDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8641-783X
David KaulDepartment of Radiation Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Johannes GollradDepartment of Radiation Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Jackie MaDepartment of Artificial Intelligence, Fraunhofer Heinrich Hertz Institute, Berlin, Germany.ORCID http://orcid.org/0000-0002-2268-1690
Christoph LippertDigital Health & Machine Learning, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany.ORCID http://orcid.org/0000-0001-6363-2556
Kendall BillickDivision of Dermatology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7777-8783
Isaac BogochDivision of Infectious Diseases, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.
Tina Hernandez-BoussardDepartment of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6553-3455
Pascal Geldsetzer *Division of Primary Care and Population Health, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8878-5505
Olivier Gevaert *Department of Medicine, Stanford University, Stanford, CA, USA.
Stanford University · USCharité - Universitätsmedizin Berlin · DEUniversity Health Network · CABerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEChan Zuckerberg Initiative (United States) · USFraunhofer Institute for Telecommunications, Heinrich Hertz Institute · DEHasso Plattner Institute · DEHeidelberg University · DEJustus-Liebig-Universität Gießen · DEStanford Medicine · USTechnische Universität Berlin · DEUniversidad de Granada · ESUniversity Hospital Schleswig-Holstein · DEUniversity of Bologna · IT

Funding

POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Stanford TRANSFORM I2T ProgramR25AI147369 · NIAID · STANFORD UNIVERSITY · PI CHERTOW, GLENN MATTHEW, SINGH, UPINDER · 2019 to 2023
$1.8M
Biomedical Data Science Graduate Training at StanfordT32LM012409 · NLM · STANFORD UNIVERSITY · PI PLEVRITIS, SYLVIA KATINA · 2016 to 2020
$1.5M
NIAID NIH HHS R25 AI147369NLM NIH HHS T15 LM007033NLM NIH HHS T32 LM012409
6 · The paper itself

Abstract

Undetected infection and delayed isolation of infected individuals are key factors driving the monkeypox virus (now termed mpox virus or MPXV) outbreak. To enable earlier detection of MPXV infection, we developed an image-based deep convolutional neural network (named MPXV-CNN) for the identification of the characteristic skin lesions caused by MPXV. We assembled a dataset of 139,198 skin lesion images, split into training/validation and testing cohorts, comprising non-MPXV images (n = 138,522) from eight dermatological repositories and MPXV images (n = 676) from the scientific literature, news articles, social media and a prospective cohort of the Stanford University Medical Center (n = 63 images from 12 patients, all male). In the validation and testing cohorts, the sensitivity of the MPXV-CNN was 0.83 and 0.91, the specificity was 0.965 and 0.898 and the area under the curve was 0.967 and 0.966, respectively. In the prospective cohort, the sensitivity was 0.89. The classification performance of the MPXV-CNN was robust across various skin tones and body regions. To facilitate the usage of the algorithm, we developed a web-based app by which the MPXV-CNN can be accessed for patient guidance. The capability of the MPXV-CNN for identifying MPXV lesions has the potential to aid in MPXV outbreak mitigation.

Indexed as

Deep LearningMpox, MonkeypoxAlgorithmsHumansMaleMonkeypox virusProspective Studies

Identifiers

PMID36864252
PMCPMC10033450
OpenAlexW4322766760

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read80
identifiers read1
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.