Evidence map›Paper›PMID 36864234›Full record

ArticleNPJ precision oncology2023

Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer.

Eleni Gkika, Elke Firat, Sonja Adebahr, Erika Graf, Ilinca Popp, Gianluca Radicioni, Simon S Lo, Ursula Nestle, Nils H Nicolay, Gabriele Niedermann and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in NPJ precision oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07173374 (Stereotactic Centralized Ablative Radiotherapy for Locally Advanced Pancreatic Cancer), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07173374 phase1suspendednot on this mapstarted 2025, after this paper: background citation

Stereotactic Centralized Ablative Radiotherapy for Locally Advanced Pancreatic Cancer: A Single-Arm Phase I Safety and Feasibility Study

TypeinterventionalSponsorShandong Cancer Hospital and InstituteRan2025 to 2028Enrolled24ConditionsPancreatic Cancer, Locally Advanced Pancreatic CancerArmsSCART Dose Escalation Arm
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Facts and Hopes in Radioimmunotherapy for Localized Stages of Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Modulation of CD8International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eleni Gkika *Department of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Elke Firat *Department of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Sonja AdebahrDepartment of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Erika GrafInstitute of Medical Biometry and Statistics, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Ilinca PoppDepartment of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Gianluca RadicioniDepartment of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Simon S LoDepartment of Radiation Oncology, University of Washington School of Medicine, Seattle, WA, USA.
Ursula NestleDepartment of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Nils H NicolayDepartment of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.ORCID http://orcid.org/0000-0003-2550-1410
Gabriele NiedermannDepartment of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.
Dan G DudaE. L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. duda@steele.mgh.harvard.edu.ORCID http://orcid.org/0000-0001-7065-8797
Anca-L GrosuDepartment of Radiation Oncology, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8

Identifiers

PMID36864234
PMCPMC9981559

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.