Evidence map›Paper›PMID 36864112›Full record

ArticleScientific reports2023

Predicting anterior cruciate ligament failure load with T

Sean W Flannery, Jillian E Beveridge, Benedikt L Proffen, Edward G Walsh, BEAR Trial Team, Dennis E Kramer, Martha M Murray, Ata M Kiapour, Braden C Fleming

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sean W FlanneryDepartment of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Coro West, Suite 402, 1 Hoppin St, Providence, RI, 02903, USA.
Jillian E BeveridgeDepartment of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Coro West, Suite 402, 1 Hoppin St, Providence, RI, 02903, USA.
Benedikt L ProffenDivision of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Edward G WalshDepartment of Neuroscience, Division of Biology and Medicine, Brown University, Providence, RI, USA.
BEAR Trial Team
Dennis E KramerDivision of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Martha M MurrayDivision of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Ata M KiapourDivision of Sports Medicine, Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Braden C FlemingDepartment of Orthopaedics, Warren Alpert Medical School of Brown University/Rhode Island Hospital, Coro West, Suite 402, 1 Hoppin St, Providence, RI, 02903, USA. braden_fleming@brown.edu.

Funding

The neural basis of sequential control in human and non-human primatesP20GM103645 · NIGMS · BROWN UNIVERSITY · PI PETZSCHNER, FREDERIKE HERMI · 2013 to 2022
$22.9M
Pilot Projects ProgramP30GM122732 · NIGMS · RHODE ISLAND HOSPITAL · PI CRISCO, JOSEPH J · 2017 to 2021
$6.6M
Biologically Enhanced Healing of Autograft ACL Reconstruction.R01AR056834 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2009 to 2017
$5.8M
Non-invasive Assessment of Ligament Healing, in VivoR01AR065462 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2014 to 2016
$2.1M
The Effects of Reduced ACL Stiffness on Dynamic In Vivo Joint FunctionR00AR069094 · NIAMS · RHODE ISLAND HOSPITAL · PI BEVERIDGE, JILLIAN ELIZABETH · 2019 to 2021
$730k
Effects of Initial ACL Graft Tension on Dynamic Joint Motion and Osteoarthritis ProgressionK99AR069094 · NIAMS · RHODE ISLAND HOSPITAL · PI BEVERIDGE, JILLIAN ELIZABETH · 2016 to 2017
$182k
NIAMS NIH HHS K99 AR069094NIAMS NIH HHS R00 AR069094NIAMS NIH HHS R01 AR056834NIAMS NIH HHS R01 AR065462NIGMS NIH HHS P20 GM103645NIGMS NIH HHS P30 GM122732NIGMS NIH HHS P30-GM122732NIH HHS K99/R00-AR069094NIH HHS R01-AR065462
6 · The paper itself

Abstract

Non-invasive methods to document healing anterior cruciate ligament (ACL) structural properties could potentially identify patients at risk for revision surgery. The objective was to evaluate machine learning models to predict ACL failure load from magnetic resonance images (MRI) and to determine if those predictions were related to revision surgery incidence. It was hypothesized that the optimal model would demonstrate a lower mean absolute error (MAE) than the benchmark linear regression model, and that patients with a lower estimated failure load would have higher revision incidence 2 years post-surgery. Support vector machine, random forest, AdaBoost, XGBoost, and linear regression models were trained using MRI T

Indexed as

Anterior Cruciate LigamentMachine LearningAnimalsBiomarkersHumansProspective StudiesReoperationSwineSwine, MiniatureBiomarkers

Identifiers

PMID36864112
PMCPMC9981601

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.