ArticleScientific reports2023
Diurnal changes in choroidal optical coherence tomography angiography indices over 24 hours in healthy young adults.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The potential role of the choroidal thickness-to-axial length ratio in primary angle-closure disease.Japanese journal of ophthalmology · 2026Observational
- Regional differences in foveal avascular zone morphology in cynomolgus macaques using a normative OCTA database.Scientific reports · 2026Article
- Association Between Pigmentation Heritage and Susceptibility to Experimentally Induced Myopia: Crossbreeding Insights From Albino and Pigmented Guinea Pigs.Investigative ophthalmology & visual science · 2025Article
- Swept-Source OCT Angiography-Derived Regional Normative Data of Peripapillary Vessel Density in Healthy Populations.Translational vision science & technology · 2025Article
- Retinal imaging in an era of open science and privacy protection.Experimental eye research · 2025Review
- Evaluating the reproducibility of a deep learning algorithm for the prediction of retinal age.GeroScience · 2025Article
- Relationship between age and subfoveal choroidal thickness and its clinical implications.World journal of diabetes · 2024Article
- Peripheral Contrast Reduction Optically Induced by Scattering Lenses Thickens Peripheral Choroid.Translational vision science & technology · 2024Article
- Coefficient of spatial variance of choroidal thickness on swept-source optical coherence tomography in healthy eyes.International ophthalmology · 2024Article
- Assessment of retinal and choroidal microvasculature in night shift medical workers by OCT angiography.Scientific reports · 2024Article
- Influence of Aberration-Free, Narrowband Light on the Choroidal Thickness and Eye Length.Translational vision science & technology · 2024Article
- Inter-Individual Topographic Variation of Choroidal Thickness in Healthy Eyes on Swept-Source Optical Coherence Tomography.Translational vision science & technology · 2024Article
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4 authors.
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Abstract
This prospective study investigated the magnitude and pattern of variation in choroidal optical coherence tomography angiography (OCT-A) indices every 4 h over 24 h in healthy young myopic (n = 24) and non-myopic (n = 20) adults. Choriocapillaris and deep choroid en-face images from macular OCT-A scans were analysed from each session to extract magnification-corrected vascular indices including choriocapillaris flow deficit number, size and density and deep choroid perfusion density in the sub-foveal, sub-parafoveal, and sub-perifoveal regions. Choroidal thickness was also obtained from structural OCT scans. Significant variations over 24 h (P < 0.05) were observed in most of the choroidal OCT-A indices excluding sub-perifoveal flow deficit number, with peaks observed between 2 to 6 AM. For myopes, peaks occurred significantly earlier (3-5 h), and the diurnal amplitude was significantly greater for sub-foveal flow deficit density (P = 0.02) and deep choroidal perfusion density (P = 0.03) compared with non-myopes. Choroidal thickness also showed significant diurnal changes (P < 0.05) with peaks between 2 to 4 AM. Significant correlations were found between diurnal amplitudes or acrophases of choroidal OCT-A indices and choroidal thickness, intraocular pressure, and systemic blood pressure. This provides the first comprehensive diurnal assessment of choroidal OCT-A indices over 24 h.
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