Evidence map›Paper›PMID 36863825›Full record

ArticleThe American journal of clinical nutrition2023

Plant-based diets and the risk of pancreatic cancer: a large prospective multicenter study.

Guo-Chao Zhong, Zhi Li, Ai-Jing You, Qian Zhu, Chun-Rui Wang, Peng-Fei Yang

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Plant-based dietary patterns and risk of esophageal cancer: A prospective cohort study spanning 17 years.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024
    Article
  16. Pancreatic cancer: Are all plant-based diets the same?The American journal of clinical nutrition · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Guo-Chao ZhongDepartment of Hepatobiliary Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: gczhong1991@hospital.cqmu.edu.cn.
Zhi LiDepartment of Breast and Thyroid Surgery, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ai-Jing YouThe Second Student Office, the Second College of Clinical Medicine, Chongqing Medical University, Chongqing, China.
Qian ZhuDepartment of Nutrition and Food Hygiene, School of Public Health and Management, Chongqing Medical University, Chongqing, China.
Chun-Rui WangDepartment of Infectious Diseases, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Peng-Fei YangDepartment of Nephrology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlant-based diets have been recommended for improving health outcomes, including cancer. However, previous studies on plant-based diets and the risk of pancreatic cancer are scarce and fail to consider plant food quality.

objectivesWe sought to examine the potential associations of 3 plant-based diet indices (PDIs) with the risk of pancreatic cancer in a US population.

methodsA population-based cohort of 101,748 US adults was identified from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. The overall PDI, healthful PDI (hPDI), and unhealthful PDI (uPDI) were constructed to qualify adherence to overall, healthy, and less healthy plant-based diets, respectively, with higher scores indicating better adherence. Multivariable Cox regression was used to compute hazard ratios (HRs) for pancreatic cancer incidence. Subgroup analysis was conducted to identify the potential effect modifiers.

resultsOver a mean follow-up of 8.86 years, 421 pancreatic cancer cases occurred. Participants in the highest compared with the lowest quartiles of overall PDI had a lower risk of pancreatic cancer [HR

conclusionsIn this US population, adherence to a healthy plant-based diet confers a lower risk of pancreatic cancer, whereas adherence to a less healthy plant-based diet confers a higher risk. These findings highlight the importance of considering plant food quality in preventing pancreatic cancer.

Indexed as

Pancreatic NeoplasmsAdultDietDiet, VegetarianHumansMaleProspective Studiesnutritional epidemiologypancreatic cancerplant-based dietsrisk factor

Identifiers

PMID36863825

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.