Evidence map›Paper›PMID 36863659›Full record

ArticleJournal of molecular biology2023

Why Does Synergistic Activation of WASP, but Not N-WASP, by Cdc42 and PIP

Souvik Dey, Huan-Xiang Zhou

Open access · greenAbstract read
In one paragraph

Article in Journal of molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Electrical Forces Improve Memory in Old Age.Reviews of physiology, biochemistry and pharmacology · 2025
    Review
  4. Neutrophil diversity and function in health and disease.Signal transduction and targeted therapy · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Souvik DeyDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: https://twitter.com/SouvikDeyUIC.
Huan-Xiang ZhouDepartment of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA; Department of Physics, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: hzhou43@uic.edu.
Twitter (United States) · USUniversity of Illinois Chicago · US

Funding

Quantitative, Mechanistic Studies of Biomolecular RecognitionR35GM118091 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Huan-Xiang Zhou · 2016 to 2026
$6.5M
NIGMS NIH HHS R35 GM118091
6 · The paper itself

Abstract

Human WASP and N-WASP are homologous proteins that require the binding of multiple regulators, including the acidic lipid PIP

Indexed as

cdc42 GTP-Binding ProteinProtein PrenylationWiskott-Aldrich Syndrome ProteinActinsHumansMolecular Dynamics SimulationPolymerizationProtein BindingWiskott-Aldrich Syndrome Protein, NeuronalActinscdc42 GTP-Binding ProteinWiskott-Aldrich Syndrome ProteinWiskott-Aldrich Syndrome Protein, Neuronalautoinhibitionintrinsically disordered proteinsPIP(2)prenylationWASP

Identifiers

PMID36863659
PMCPMC10079582
OpenAlexW4322627104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.