ArticleNeuron2023
A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
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Article in Neuron, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- HSPA8 orchestrates SNARE complex assembly to drive extracellular vesicle-mediated spread of p-tau217 in Alzheimer's disease.Translational neurodegeneration · 2026Article
- Are components of the histone gene expression machinery functionally repurposed in terminally differentiated cells?Biology open · 2026Article
- SMN deficiency contributes to osteoporosis in spinal muscular atrophy by impairing Snap23 meditated muscle-derived extracellular vesicle secretion.Journal of translational medicine · 2026Article
- A therapeutic role for a regulatory GLUT1-associated lncRNA in GLUT1-deficient mice.The Journal of clinical investigation · 2026Article
- Astrocyte targeted SMN1 gene therapy and forskolin application improves astrocyte filopodia actin defects and motor neuron synaptic dysfunction in human SMA disease pathology.bioRxiv : the preprint server for biology · 2026Article
- Loss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP.Molecular psychiatry · 2026Article
- The survival motor neuron protein: structure, functions, stability, and therapeutic targeting.Frontiers in cellular neuroscience · 2026Review
- Immaturity of the neuromuscular junction in spinal muscular atrophy mouse models.Frontiers in cellular neuroscience · 2026Review
- Novel Translational Concept: Axon-to-Muscle Exosomal Signaling as an Emerging Therapeutic Target in Spinal Muscular Atrophy.Biomedicines · 2025Review
- Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy.Nature communications · 2025Article
- Exploring Protein Misfolding in Amyotrophic Lateral Sclerosis: Structural and Functional Insights.Biomedicines · 2025Review
- Chaperone dysfunction in motor neuron disease: new insights from studies of the SMN complex.Genetics · 2025Review
- A variant of the Hspa8 synaptic chaperone modifies disease in a SOD1Experimental neurology · 2025Article
- Biomarkers in spinal muscular atrophy.Frontiers in neurology · 2025Review
- Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis.Nature communications · 2024Article
- In Search of Spinal Muscular Atrophy Disease Modifiers.International journal of molecular sciences · 2024Review
- Clinical and Genetic Profiles of 5q- and Non-5q-Spinal Muscular Atrophy Diseases in Pediatric Patients.Genes · 2024Review
- Chaperoning the chaperones: Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network.bioRxiv : the preprint server for biology · 2024Article
- Exploring lncRNA Expression Patterns in Patients With Hypertrophied Ligamentum Flavum.Neurospine · 2024Article
- Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network.Frontiers in RNA research · 2024Article
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Authors and funding
18 authors at 5 institutions in 2 countries.
Jeong-Ki KimDepartment of Neurology, New York, NY, USA; Center for Motor Neuron Biology & Disease, New York, NY, USA.
Narendra N JhaDepartment of Neurology, New York, NY, USA; Center for Motor Neuron Biology & Disease, New York, NY, USA.
Tomoyuki AwanoDepartment of Neurology, New York, NY, USA; Center for Motor Neuron Biology & Disease, New York, NY, USA.
Charlotte CaineDepartment of Neurology, New York, NY, USA; Center for Motor Neuron Biology & Disease, New York, NY, USA.
Kishore GollapalliDepartment of Neurology, New York, NY, USA; Center for Motor Neuron Biology & Disease, New York, NY, USA.
Emily WelbyDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Seung-Soo KimDepartment of Obstetrics and Gynecology, New York, NY, USA.
Andrea Fuentes-MolizDepartment of Medical Physiology and Biophysics, University of Seville School of Medicine, 41009, Seville, Spain.
Xueyong WangDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435, USA.
Zhihua FengDepartment of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Fusako SeraDepartment of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Taishi TakedaDepartment of Neurology, New York, NY, USA; Center for Motor Neuron Biology & Disease, New York, NY, USA.
Shunichi HommaDepartment of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Chien-Ping KoDepartment of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Lucia TabaresDepartment of Medical Physiology and Biophysics, University of Seville School of Medicine, 41009, Seville, Spain.
Allison D EbertDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Mark M RichDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435, USA.
Umrao R MonaniDepartment of Neurology, New York, NY, USA; Department of Pathology & Cell Biology, New York, NY, USA; Center for Motor Neuron Biology & Disease, New York, NY, USA; Colleen Giblin Research Laboratory, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: um2105@columbia.edu.
Columbia University Irving Medical Center · USMedical College of Wisconsin · USUniversidad de Sevilla · ESUniversity of Southern California · USWright State University · US
Funding
Novel Approaches to Therapy of Muscle Ion ChannelopathiesR01AR074985 · NIAMS · WRIGHT STATE UNIVERSITY · PI MARK M RICH · 2019 to 2026
$3.9MMechanisms and SMN-Independent Therapies for Spinal Muscular AtrophyR01NS123292 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Umrao Monani · 2022 to 2026
$2.5MSpinal muscular atrophy: Mechanisms & treatment strategies.R01NS104218 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MONANI, UMRAO · 2019 to 2022
$2.0MSpinal muscular atrophy: Mechanisms and treatment strategies.R56NS104218 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MONANI, UMRAO · 2018 to 2018
$533kMechanistic link between GATA factors, SMN, and astrocyte senescence in SMA pathologyR21NS102911 · NINDS · MEDICAL COLLEGE OF WISCONSIN · PI EBERT, ALLISON D · 2018 to 2019
$424kNIAMS NIH HHS R01 AR074985NINDS NIH HHS R01 NS104218NINDS NIH HHS R01 NS123292NINDS NIH HHS R21 NS102911NINDS NIH HHS R56 NS104218
Abstract
Reduced survival motor neuron (SMN) protein triggers the motor neuron disease, spinal muscular atrophy (SMA). Restoring SMN prevents disease, but it is not known how neuromuscular function is preserved. We used model mice to map and identify an Hspa8
Indexed as
Muscular Atrophy, SpinalAnimalsDisease Models, AnimalMiceMotor NeuronsSNARE ProteinsSurvival of Motor Neuron 1 ProteinSynapsesSynaptic TransmissionTranscription FactorsSNARE ProteinsSurvival of Motor Neuron 1 ProteinTranscription FactorsHspa8modifiersSNARE complex assemblyspinal muscular atrophysurvival motor neuron protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.