Evidence map›Paper›PMID 36863336›Full record

ArticleCell reports. Medicine2023

Bioengineered omental transplant site promotes pancreatic islet allografts survival in non-human primates.

Hongping Deng, Alexander Zhang, Dillon Ren Rong Pang, Yinsheng Xi, Zhihong Yang, Rudy Matheson, Guoping Li, Hao Luo, Kang M Lee, Qiang Fu and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  7. Scaling Insulin-Producing Cells by Multiple Strategies.Endocrinology and metabolism (Seoul, Korea) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 2 countries.

Hongping DengCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Alexander ZhangCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Dillon Ren Rong PangCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Yinsheng XiSchool of Clinical Medicine, Southern Medical University, Foshan 528300, China.
Zhihong YangCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Rudy MathesonCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Guoping LiCardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Hao LuoCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Kang M LeeCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Qiang FuCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Zhongliang ZouCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Tao ChenCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Zhenjuan WangCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ivy A RosalesCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Cole W PetersCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Jibing YangCenter for Comparative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
María M CoronelWoodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
Esma S YolcuDepartments of Child Health and Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA.
Haval ShirwanDepartments of Child Health and Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO, USA.
Andrés J GarcíaWoodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.
James F MarkmannCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ji LeiCenter for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: jlei2@mgh.harvard.edu.
Harvard University · USGeorgia Institute of Technology · USUniversity of Missouri Health System · USMassachusetts General Hospital · USSouthern Medical University · CN

Funding

Hydrogels for human beta cell survival, function and evasion of immune rejectionR01DK133702 · NIDDK · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J, LEI, JI · 2022 to 2025
$3.3M
A novel immunomodulatory approach to overcome innate and adaptiveimmune barriers to islet transplantationR01AI121281 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI SHIRWAN, HAVAL · 2019 to 2024
$1.9M
NIAID NIH HHS R01 AI121281NIDDK NIH HHS R01 DK133702
6 · The paper itself

Abstract

The transplanting islets to the liver approach suffers from an immediate posttransplant loss of islets of more than 50%, progressive graft dysfunction over time, and precludes recovery of grafts should there be serious complications such as the development of teratomas with grafts that are stem cell-derived islets (SC-islets). The omentum features an attractive extrahepatic alternative site for clinical islet transplantation. We explore an approach in which allogeneic islets are transplanted onto the omentum, which is bioengineered with a plasma-thrombin biodegradable matrix in three diabetic non-human primates (NHPs). Within 1 week posttransplant, each transplanted NHP achieves normoglycemia and insulin independence and remains stable until termination of the experiment. Success was achieved in each case with islets recovered from a single NHP donor. Histology demonstrates robust revascularization and reinnervation of the graft. This preclinical study can inform the development of strategies for β cell replacement including the use of SC-islets or other types of novel cells in clinical settings.

Indexed as

Islets of LangerhansIslets of Langerhans TransplantationAllograftsAnimalsOmentumPrimatesTransplantation, Homologousallogeneic islet transplantationbioengineering the omentumeuglycemiagraft survivalnon-human primateplasma-thrombin matrixrevascularization and reinnervationsingle donorstem cell-derived islets

Identifiers

PMID36863336
PMCPMC10040375
OpenAlexW4322733042

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.