Evidence map›Paper›PMID 36863329›Full record

GuidelineNeonatology2023

European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update.

David G Sweet, Virgilio P Carnielli, Gorm Greisen, Mikko Hallman, Katrin Klebermass-Schrehof, Eren Ozek, Arjan Te Pas, Richard Plavka, Charles C Roehr, Ola D Saugstad and 5 more

4 registry-linked trialsAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Neonatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 386 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
386citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06224816 narecruitingnot on this mapstarted 2024, after this paper: background citation

Clinical Trial to Assess the Clinical Impact, Efficacy and Safety of Customized Nasal Masks Designed by 3D Printing During Non-invasive Ventilation in Premature Infants

TypeinterventionalSponsorHospital Universitario 12 de OctubreRan2024 to 2026Enrolled60ConditionsPremature LungsArmsCustom 3D mask (3DM) application in neonate, Traditional mask (TM) application in neonate
NCT07324941 recruitingnot on this mapstarted 2026, after this paper: background citation

The Role of Electroencephalography Evaluation in Caffeine Discontinuation Timing in Premature Infants

Typeobservational_patient_registrySponsorUludag UniversityRan2026 to 2027Enrolled100ConditionsApnea Neonatal, Apnea of Prematurity
NCT07350018 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of the Efficacy of Calfactant and Poractant Alfa Surfactants Administered by a Less Invasive Surfactant Administration Technique in Preterm Infants With Respiratory Distress Syndrome

TypeinterventionalSponsorUludag UniversityRan2026 to 2027Enrolled234ConditionsRespiratory Distress Syndrome in Premature Infants, Respiratory Distress Syndrome (RDS), SurfactantArmsPoractant alfa, Calfactant
NCT07693530 nacompletednot on this map

Heated Humidified High-Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure as Primary Respiratory Support in Preterm Infants With Respiratory Distress Syndrome: A Randomized Controlled Trial

TypeinterventionalSponsorKayseri City HospitalRan2020 to 2022Enrolled86ConditionsPremature Birth, Respiratory Distress Syndrome, NewbornArmsGroup 1 Heated humidified high-flow nasal cannula (HHHFNC), Group 2 Nasal continuous positive airway pressure (nCPAP)
3 · Its place in the literature

Who cites it

386 citing papers in PubMed, 11 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Guideline
  12. Initial CPAP of 5 versus 8 cmHEuropean journal of pediatrics · 2026
    Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

326 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

David G SweetRegional Neonatal Unit, Royal Maternity Hospital, Belfast, UK.
Virgilio P CarnielliDepartment of Neonatology, University Polytechnic Della Marche, University Hospital Ancona, Ancona, Italy.
Gorm GreisenDepartment of Neonatology, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark.
Mikko HallmanDepartment of Children and Adolescents, Oulu University Hospital and Medical Research Center, University of Oulu, Oulu, Finland.
Katrin Klebermass-SchrehofDepartment of Pediatrics and Adolescent Medicine, Division of Neonatology, Medical University of Vienna, Vienna, Austria.
Eren OzekDepartment of Pediatrics, Marmara University Medical Faculty, Istanbul, Turkey.
Arjan Te PasLeiden University Medical Centre, Leiden, The Netherlands.
Richard PlavkaDivision of Neonatology, Department of Obstetrics and Gynecology, General Faculty Hospital and 1st Faculty of Medicine, Charles University, Prague, Czechia.
Charles C RoehrFaculty of Health Sciences, University of Bristol, UK and National Perinatal Epidemiology Unit, Oxford Population Health, Medical Sciences Division, University of Oxford, Oxford, UK.
Ola D SaugstadDepartment of Pediatric Research, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway.
Umberto SimeoniUniversity of Lausanne, Lausanne, Switzerland.
Christian P SpeerDepartment of Pediatrics, University Children's Hospital, Wuerzburg, Germany.
Maximo VentoDepartment of Pediatrics and Neonatal Research Unit, Health Research Institute La Fe, University and Polytechnic Hospital La Fe, Valencia, Spain.
Gerry H A VisserDepartment of Obstetrics and Gynecology, University Medical Centre, Utrecht, The Netherlands.
Henry L HallidayDepartment of Child Health, Queen's University Belfast and Royal Maternity Hospital, Belfast, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory distress syndrome (RDS) care pathways evolve slowly as new evidence emerges. We report the sixth version of "European Guidelines for the Management of RDS" by a panel of experienced European neonatologists and an expert perinatal obstetrician based on available literature up to end of 2022. Optimising outcome for babies with RDS includes prediction of risk of preterm delivery, appropriate maternal transfer to a perinatal centre, and appropriate and timely use of antenatal steroids. Evidence-based lung-protective management includes initiation of non-invasive respiratory support from birth, judicious use of oxygen, early surfactant administration, caffeine therapy, and avoidance of intubation and mechanical ventilation where possible. Methods of ongoing non-invasive respiratory support have been further refined and may help reduce chronic lung disease. As technology for delivering mechanical ventilation improves, the risk of causing lung injury should decrease, although minimising time spent on mechanical ventilation by targeted use of postnatal corticosteroids remains essential. The general care of infants with RDS is also reviewed, including emphasis on appropriate cardiovascular support and judicious use of antibiotics as being important determinants of best outcome. We would like to dedicate this guideline to the memory of Professor Henry Halliday who died on November 12, 2022.These updated guidelines contain evidence from recent Cochrane reviews and medical literature since 2019. Strength of evidence supporting recommendations has been evaluated using the GRADE system. There are changes to some of the previous recommendations as well as some changes to the strength of evidence supporting recommendations that have not changed. This guideline has been endorsed by the European Society for Paediatric Research (ESPR) and the Union of European Neonatal and Perinatal Societies (UENPS).

Indexed as

Respiratory Distress SyndromeRespiratory Distress Syndrome, NewbornAnti-Bacterial AgentsChildCognitionConsensusFemaleHumansInfantInfant, NewbornPregnancyAnti-Bacterial AgentsAntenatal corticosteroidsContinuous positive airway pressureEvidence-based practiceMechanical ventilationNon-invasive respiratory supportNutritionOxygen supplementationPatent ductus arteriosusPreterm infantRespiratory distress syndromeSurfactant therapyThermoregulation

Identifiers

PMID36863329
PMCPMC10064400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.