Evidence map›Paper›PMID 36862938›Full record

ArticleACS applied bio materials2023

One-Pot Preparation of Cetylpyridinium Chloride-Containing Nanoparticles for Biofilm Eradication.

Alexander Brezhnev, Fung-Kit Tang, Chak-Shing Kwan, Mohammed S Basabrain, James Kit Hon Tsoi, Jukka P Matinlinna, Prasanna Neelakantan, Ken Cham-Fai Leung

Open access · hybridFull text read
In one paragraph

Article in ACS applied bio materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
  6. Microbiological and toxicity analyses of the synthetic polymer polyhexamethylene guanidine hydrochloride against endodontic microorganisms.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Alexander BrezhnevRestorative Dental Sciences, Discipline of Endodontology, Faculty of Dentistry, The University of Hong Kong, Hong Kong Island, Hong Kong SAR, P. R. China.ORCID 0000-0001-6399-3124
Fung-Kit TangDepartment of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China.
Chak-Shing KwanDepartment of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China.ORCID 0000-0002-1289-6620
Mohammed S BasabrainRestorative Dental Sciences, Discipline of Endodontology, Faculty of Dentistry, The University of Hong Kong, Hong Kong Island, Hong Kong SAR, P. R. China.
James Kit Hon TsoiApplied Oral Sciences and Community Dental Care, Dental Materials Science, Faculty of Dentistry, The University of Hong Kong, Hong Kong Island, Hong Kong SAR, P. R. China.ORCID 0000-0002-0698-7155
Jukka P MatinlinnaApplied Oral Sciences and Community Dental Care, Dental Materials Science, Faculty of Dentistry, The University of Hong Kong, Hong Kong Island, Hong Kong SAR, P. R. China.
Prasanna NeelakantanRestorative Dental Sciences, Discipline of Endodontology, Faculty of Dentistry, The University of Hong Kong, Hong Kong Island, Hong Kong SAR, P. R. China.ORCID 0000-0003-3025-7598
Ken Cham-Fai LeungDepartment of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China.ORCID 0000-0002-0349-0418
University of Hong Kong · HKHong Kong Baptist University · HKUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quaternary ammonium compounds (QACs) have been widely used due to their excellent antimicrobial activity. However, using the technology where nanomaterials are employed as drug carriers to deliver QAC drugs has not been fully explored. In this study, mesoporous silica nanoparticles (MSNs) with short rod morphology were synthesized in a one-pot reaction using an antiseptic drug cetylpyridinium chloride (CPC). CPC-MSN were characterized via various methods and tested against three bacterial species (

Indexed as

Anti-Infective Agents, LocalNanoparticlesBiofilmsCetylpyridiniumStreptococcus mutansAnti-Infective Agents, LocalCetylpyridiniumantimicrobialbiofilm eradicationcetylpyridinium chloridedrug deliverymesoporous silica nanoparticles

Identifiers

PMID36862938
PMCPMC10031565
OpenAlexW4322756277

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read94
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.