Evidence map›Paper›PMID 36862511›Full record

ArticleThe Journal of clinical investigation2023

Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock.

Yohan Bignon, Leonore Wigger, Camille Ansermet, Benjamin D Weger, Sylviane Lagarrigue, Gabriel Centeno, Fanny Durussel, Lou Götz, Mark Ibberson, Sylvain Pradervand and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
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  5. Article
  6. Deletion ofInternational journal of molecular sciences · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Bioinformatics advances · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Circadian Control of Protein Synthesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  16. Article
  17. PERspectives on circadian cell biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Yohan BignonDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Leonore WiggerDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Camille AnsermetDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Benjamin D WegerInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Sylviane LagarrigueDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Gabriel CentenoDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Fanny DurusselDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Lou GötzVital-IT, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Mark IbbersonVital-IT, Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Sylvain PradervandGenomic Technologies Facility, University of Lausanne, Lausanne, Switzerland.
Manfredo QuadroniProtein Analysis Facility, University of Lausanne, Lausanne, Switzerland.
Meltem WegerInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Francesca AmatiDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Frédéric GachonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Dmitri FirsovDepartment of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
University of Lausanne · CHSIB Swiss Institute of Bioinformatics · CHThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism. To decipher the role of the circadian clock in renal metabolism, we studied diurnal changes in renal metabolic pathways using integrated transcriptomic, proteomic, and metabolomic analysis performed on control mice and mice with an inducible deletion of the circadian clock regulator Bmal1 in the renal tubule (cKOt). With this unique resource, we demonstrated that approximately 30% of RNAs, approximately 20% of proteins, and approximately 20% of metabolites are rhythmic in the kidneys of control mice. Several key metabolic pathways, including NAD+ biosynthesis, fatty acid transport, carnitine shuttle, and β-oxidation, displayed impairments in kidneys of cKOt mice, resulting in perturbed mitochondrial activity. Carnitine reabsorption from primary urine was one of the most affected processes with an approximately 50% reduction in plasma carnitine levels and a parallel systemic decrease in tissue carnitine content. This suggests that the circadian clock in the renal tubule controls both kidney and systemic physiology.

Indexed as

Circadian ClocksAnimalsARNTL Transcription FactorsCarnitineCircadian RhythmKidneyMiceMultiomicsProteomicsARNTL Transcription FactorsCarnitineBioenergeticsBioinformaticsFatty acid oxidationNephrology

Identifiers

PMID36862511
PMCPMC10104904
OpenAlexW4322758960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.