ArticleThe Eurasian journal of medicine2023
Evaluating the Cytotoxic Effect of Melatonin and Oxyresveratrol on Dental Pulp Stem Cells.
Article in The Eurasian journal of medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Histological evaluation of pulpal healing following direct pulp capping with polytetrafluoroethylene or melatonin, with or without adjunctive low-level laser therapy in Wistar rat molars.Scientific reports · 2026Article
- Melatonin and the Dental Pulp: A Scoping Review.International endodontic journal · 2026Article
- Role of necroptosis in pulpitis: integration of bacterial infection, immune imbalance, and oxidative stress.PeerJ · 2025Review
- The effects of melatonin on the viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla.Molecular biology reports · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHypoxia in the pulpitis process, the use of bleaching agents, and resin-containing materials produce reactive oxygen species. Their damage to the pulp tissue can be eliminated by melatonin and oxyresveratrol. However, the cytotoxic effects of these antioxidants on dental pulp stem cells are not well known. The aim of this study was to observe the cytotoxic effects of melatonin and oxyresveratrol for 72 hours on dental pulp stem cells. MATERIALS AND
methodsHuman dental pulp stem cells obtained from the American Type Culture Collection were seeded on E-Plates®, and after 24 hours, 3 different doses of melatonin (100 pM, 100 nM, and 100 μM) and oxyresveratrol (10 μM, 25 μM, and 50 μM) were added. Real-time cell index data was acquired by using xCELLigence® device for 72 hours and inhibitor concentration (IC50) values of experimental groups were obtained. Analysis of covariance was used to compare the cell index values.
resultsIn comparison with the control group; oxyresveratrol 10 μM and melatonin 100 pM groups increased proliferation whereas oxyresveratrol 25 μM, oxyresveratrol 50 μM, and melatonin 100 μM groups induced cytotoxicity (P < .05). IC50 values at 24th, 48th, and 72th hours were 946 nM, 1220 nM, and 1243 nM for melatonin and 23 μM, 22.2 μM, and 22.5 μM for oxyresveratrol, respectively.
conclusionCytotoxicity of melatonin was higher than oxyresveratrol and they both increased dental pulp stem cells' proliferation at lower doses and induced cytotoxicity at higher doses.
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Registered trials
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