Evidence map›Paper›PMID 36861835›Full record

ArticleSTAR protocols2023

Targeted delivery of therapeutic agents to the mouse brain using a stereotactic-guided focused ultrasound device.

Zhongtao Hu, Yaoheng Yang, Dezhuang Ye, Si Chen, Yan Gong, Chinwendu Chukwu, Hong Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in STAR protocols, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Mechanically manipulating glymphatic transport by ultrasound combined with microbubbles.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhongtao HuDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA. Electronic address: zhongtaohu@wustl.edu.
Yaoheng YangDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Dezhuang YeDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Si ChenDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Yan GongDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Chinwendu ChukwuDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA.
Hong ChenDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO 63130, USA; Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO 63108, USA. Electronic address: hongchen@wustl.edu.
Washington University in St. Louis · US

Funding

Image-guided focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)R01EB027223 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2019 to 2026
$4.3M
Focused ultrasound-enabled brain tumor liquid biopsy (FUS-LBx) supplementR01EB030102 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2020 to 2026
$4.3M
FOCUS: FUNCTIONAL OPTICAL IMAGING FEEDBACK-CONTROLLED CELLULAR-LEVEL ULTRASOUND STIMULATIONR01MH116981 · NIMH · WASHINGTON UNIVERSITY · PI CHEN, HONG · 2018 to 2021
$2.8M
iSonogenetics for incisionless cell-type-specific neuromodulation of non-human primate brainsUG3MH126861 · NIMH · WASHINGTON UNIVERSITY · PI CHEN, HONG, MONOSOV, ILYA E. · 2021 to 2023
$2.1M
NIBIB NIH HHS R01 EB027223NIBIB NIH HHS R01 EB030102NIMH NIH HHS R01 MH116981NIMH NIH HHS UG3 MH126861
6 · The paper itself

Abstract

Existing protocols of focused ultrasound (FUS) combined with microbubble-mediated blood-brain barrier (BBB) opening (FUS-BBBO) in preclinical research require expensive ultrasound equipment and complex operating procedures. We developed a low-cost, easy-to-use, and precise FUS device for small animal models in preclinical research. Here, we provide a detailed protocol for building the FUS transducer, attaching the transducer to a stereotactic frame for precise brain targeting, applying the integrated FUS device to perform FUS-BBBO in mice, and evaluating the FUS-BBBO outcome. For complete details on the use and execution of this protocol, please refer to Hu et al. (2022).

Indexed as

Blood-Brain BarrierBrainAnimalsBiological TransportMiceMicrobubblesUltrasonographyBiotechnology and bioengineeringCancerHealth SciencesNeurosciencePhysics

Identifiers

PMID36861835
PMCPMC9988659
OpenAlexW4321767434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.