ArticleCombinatorial chemistry & high throughput screening2026
Synthesis, QSAR Study and Pharmacological Evaluation of Novel Triazolidine-2-thione Analogues as Antimicrobial, Anti-inflammatory and Antioxidant Agents.
Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Nano-NiFeNanoscale advances · 2026Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundThe triazole analogues are molecules of immense attraction because of their wide pharmacological applications.
methodsPresent research deals with the synthesis of triazole-2-thione analogues and their QSAR study. The synthesized analogs are also evaluated for their antimicrobial, anti-inflammatory, and antioxidant effect.
resultsIt was revealed that the benzamide analogues (3a, 3d) and triazolidine analogue (4b) were found to be most active against P. aeruginosa and E. coli with pMIC values of 1.69, 1.69 and 1.72, respectively. The antioxidant study of the derivatives showed that 4b was the most active antioxidant with 79% protein denaturation inhibition. The highest anti-inflammatory activity was shown by 3f, 4a and 4f.
conclusionThis study provides certain potent leads for further development of more potential anti- inflammatory, antioxidant and antimicrobial agents.
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