Evidence map›Paper›PMID 36861672›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2023

The spatial-temporal dynamics of pulmonary blood flow are altered in pulmonary arterial hypertension.

Abhilash S Kizhakke Puliyakote, G Kim Prisk, Ann R Elliott, Nick H Kim, Beni Pazar, Rui Carlos Sá, Amran K Asadi, Susan R Hopkins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Abhilash S Kizhakke PuliyakotePulmonary Imaging Laboratory, UC San Diego Health Sciences, San Diego, California, United States.ORCID 0000-0003-4541-0786
G Kim PriskDepartment of Radiology, University of California, San Diego, California, United States.ORCID 0000-0002-6344-4720
Ann R ElliottPulmonary Imaging Laboratory, UC San Diego Health Sciences, San Diego, California, United States.
Nick H KimDepartment of Medicine, University of California, San Diego, California, United States.
Beni PazarPulmonary Imaging Laboratory, UC San Diego Health Sciences, San Diego, California, United States.
Rui Carlos SáPulmonary Imaging Laboratory, UC San Diego Health Sciences, San Diego, California, United States.ORCID 0000-0002-8885-8671
Amran K AsadiPulmonary Imaging Laboratory, UC San Diego Health Sciences, San Diego, California, United States.
Susan R HopkinsPulmonary Imaging Laboratory, UC San Diego Health Sciences, San Diego, California, United States.ORCID 0000-0002-8672-0986
UC San Diego Health System · USUniversity of California San Diego · US

Funding

Proton MRI to measure lung ventilation and perfusionR01HL119263 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PRISK, GORDON KIM · 2014 to 2017
$3.6M
Imaging Blood Flow, Ventilation, and Density InteractionsR01HL119201 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.5M
Imaging Hypoxic Pulmonary Vasoconstriction in the Aging Lung with Proton MRIR01HL129990 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2016 to 2019
$2.4M
Imaging of pulmonary arterial hypertension with proton MRIR56HL159710 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOPKINS, SUSAN R · 2022 to 2022
$684k
NHLBI NIH HHS R01 HL119201NHLBI NIH HHS R01 HL119263NHLBI NIH HHS R01 HL129990NHLBI NIH HHS R56 HL159710
6 · The paper itself

Abstract

Global fluctuation dispersion (FDglobal), a spatial-temporal metric derived from serial images of the pulmonary perfusion obtained with MRI-arterial spin labeling, describes temporal fluctuations in the spatial distribution of perfusion. In healthy subjects, FDglobal is increased by hyperoxia, hypoxia, and inhaled nitric oxide. We evaluated patients with pulmonary arterial hypertension (PAH, 4F, aged 47 ± 15, mean pulmonary artery pressure 48 ± 7 mmHg) and healthy controls (CON, 7F, aged 47 ± 12) to test the hypothesis that FDglobal is increased in PAH. Images were acquired at ∼4-5 s intervals during voluntary respiratory gating, inspected for quality, registered using a deformable registration algorithm, and normalized. Spatial relative dispersion (RD = SD/mean) and the percent of the lung image with no measurable perfusion signal (%NMP) were also assessed. FDglobal was significantly increased in PAH (PAH = 0.40 ± 0.17, CON = 0.17 ± 0.02,

Indexed as

Pulmonary Arterial HypertensionPulmonary CirculationFemaleHumansLungMagnetic Resonance ImagingProtonsProtonsarterial spin labelingfluctuation dispersionfunctional lung imagingperfusion defectpulmonary vascular dynamics

Identifiers

PMID36861672
PMCPMC10085549
OpenAlexW4322757414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.