ReviewEndoscopic ultrasound
Efficacy and safety of EUS-guided gallbladder drainage for rescue treatment of malignant biliary obstruction: A systematic review and meta-analysis.
Review in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06375967 (Multicenter Study of EUS-guided Gallbladder Drainage vs Choledochoduodenostomy as First Line in Malignant Distal Obstruction in Palliative Patients), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Study of EUS-guided Gallbladder Drainage vs Choledochoduodenostomy as First Line in Malignant Distal Obstruction in Palliative Patients (CARPEGIEM Trial): an Open-label, Randomized Controlled Clinical Trial
Who cites it
28 citing papers in PubMed.
- Endoscopic ultrasound-guided gallbladder drainage versus choledochoduodenostomy for distal malignant biliary obstruction.Surgical endoscopy · 2026Article
- Endoscopic Ultrasound-Guided Gallbladder Drainage for Malignant Distal Biliary Obstruction: Current Evidence, Technical Considerations, and Future Directions.Medicina (Kaunas, Lithuania) · 2026Review
- Predicting Postoperative Survival in Patients With Malignant Biliary Obstruction Using an Interpretable Machine Learning Model: A Multicenter Study.Cancer medicine · 2026Article
- Role of Endoscopy in Malignant Biliary Obstruction.Diagnostics (Basel, Switzerland) · 2026Review
- Review
- Timing and other factors influencing shortterm outcomes of endoscopic transpapillary gallbladder drainage for acute cholecystitis: a retrospective study.BMC gastroenterology · 2025Article
- Review
- Sex-related association between smoke exposure and gallstones in a US population: a cross-sectional study.BMC public health · 2025Article
- Effectiveness of endoscopic ultrasound (EUS)-guided choledochoduodenostomy vs. EUS-guided gallbladder drainage for jaundice in patients with malignant distal biliary obstruction after failed endoscopic retrograde cholangiopancreatography: Retrospective, multicenter study (GALLBLADEUS Study).Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025Article
- Endoscopic ultrasound-guided gallbladder drainage for distal malignant biliary obstruction: Outcomes from a multicenter cohort.Endoscopy international open · 2025Article
- The Role of Therapeutic Endoscopic Ultrasound in Management of Malignant Double Obstruction (Biliary and Gastric Outlet): A Comprehensive Review with Clinical Scenarios.Journal of clinical medicine · 2024Review
- Biliary drainage in patients with malignant distal biliary obstruction: results of an Italian consensus conference.Surgical endoscopy · 2024Article
- Endoscopic Management of Benign Gallbladder Diseases.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Review
- Role of endoscopic ultrasound-guided biliary drainage for palliation of malignant biliary obstruction.World journal of gastrointestinal surgery · 2024Article
- Endoscopic Gallbladder Drainage: A Comprehensive Review on Indications, Techniques, and Future Perspectives.Medicina (Kaunas, Lithuania) · 2024Review
- Transluminal antegrade drill dilation technique for hepaticojejunostomy stricture with cholangioscopic evaluation (with video).Endoscopy international open · 2024Article
- Use of endoscopic ultrasound-guided gallbladder drainage as a rescue approach in cases of unsuccessful biliary drainage.World journal of gastroenterology · 2024Review
- The past, present, and future of endoscopic management for biliary strictures: technological innovations and stent advancements.Frontiers in medicine · 2024Review
- A review of endoscopic ultrasound-guided gallbladder drainage and gastroenterostomy: assisted approaches and comparison with alternative techniques.Therapeutic advances in gastroenterology · 2024Review
- Full metal jacket: salvage of EUS-guided gallbladder drainage.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ERCP is the first line of treatment for malignant biliary obstruction and EUS-guided biliary drainage (EUS-BD) is usually used for patients who have failed ERCP. EUS-guided gallbladder drainage (EUS-GBD) has been suggested as a rescue treatment for patients who fail EUS-BD and ERCP. In this meta-analysis, we have evaluated the efficacy and safety of EUS-GBD as a rescue treatment of malignant biliary obstruction after failed ERCP and EUS-BD. We reviewed several databases from inception to August 27, 2021, to identify studies that evaluated the efficacy and/or safety of EUS-GBD as a rescue treatment in the management of malignant biliary obstruction after failed ERCP and EUS-BD. Our outcomes of interest were clinical success, adverse events, technical success, stent dysfunction requiring intervention, and difference in mean pre- and postprocedure bilirubin. We calculated pooled rates with 95% confidence intervals (CI) for categorical variables and standardized mean difference (SMD) with 95% CI for continuous variables. We analyzed data using a random-effects model. We included five studies with 104 patients. Pooled rates (95% CI) of clinical success and adverse events were 85% (76%, 91%) and 13% (7%, 21%). Pooled rate (95% CI) for stent dysfunction requiring intervention was 9% (4%, 21%). The postprocedure mean bilirubin was significantly lower compared to preprocedure bilirubin, SMD (95% CI): -1.12 (-1.62--0.61). EUS-GBD is a safe and effective option to achieve biliary drainage after unsuccessful ERCP and EUS-BD in patients with malignant biliary obstruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.