Evidence map›Paper›PMID 36861129›Full record

ArticleFrontiers in genetics2023

Promoter methylation might shift the balance of Galectin-3 & 12 expression in

Magda Assem, Rady E El-Araby, Ahmed A Al-Karmalawy, Reem Nabil, Mohamed A M Kamal, Amany Belal, Heba I Ghamry, Mohammed A S Abourehab, Mohammed M Ghoneim, Mohammad Y Alshahrani and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 3 countries.

Magda AssemClinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Rady E El-ArabyDivision of Oral Biology, Department of Periodontology, Tufts University School of Medicine, Boston, MA, United States.
Ahmed A Al-KarmalawyPharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.
Reem NabilClinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Mohamed A M KamalClinical Pathology Department, El-Hussein University Hospital, Al-Azhar University, Cairo, Egypt.
Amany BelalMedicinal Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Heba I GhamryDepartment of Home Economics, College of Home Economics, King Khalid University, Abha, Saudi Arabia.
Mohammed A S AbourehabDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Minia University, Minia, Egypt.
Mohammed M GhoneimDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia.
Mohammad Y AlshahraniResearch Center for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia.
Asmaa A El LeithyCollege of Biotechnology, Misr University for Science and Technology (MUST), Giza, Egypt.
Cairo University · EGKing Khalid University · SAAhram Canadian University · EGAl-Azhar University · EGAlmaarefa UniversityBeni-Suef University · EGMinia University · EGMisr University for Science and Technology · EGTheodor Bilharz Research Institute · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) was reported as the most common type of leukemia among adults. Galectins constitute a family of galactose-binding proteins reported to play a critical role in many malignancies including AML. Galectin-3 and -12 are members of the mammalian galectin family. To understand the contribution of galectin-3 and -12 promoter methylation to their expression, we performed bisulfite methylation-specific (MSP)-PCR and bisulfite genomic sequencing (BGS) of primary leukemic cells in patients with

Indexed as

acute myeloid leukemiagalectin-12galectin-3PCRpromoter methylation

Identifiers

PMID36861129
PMCPMC9968970
OpenAlexW4320494479

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.