ArticleTherapeutic advances in musculoskeletal disease2023
Early Osteoarthritis Questionnaire (EOAQ): a tool to assess knee osteoarthritis at initial stage.
Article in Therapeutic advances in musculoskeletal disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Laboratory-selected, probioticFrontiers in nutrition · 2026Trial
- Associated factors influencing pain and slower gait speed in older adults with knee osteoarthritis: a cross-sectional study.Frontiers in medicine · 2026Article
- Lateral Meniscus Hypermobility Is Associated With Popliteomeniscal Fascicle Injuries in Patients With Varus Knee Osteoarthritis Undergoing Medial Opening-Wedge High Tibial Osteotomy.Arthroscopy, sports medicine, and rehabilitation · 2025Article
- Association between the immune-inflammation indicators and osteoarthritis - NHANES 1999-2018.Osteoarthritis and cartilage open · 2025Article
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- Machine learning for clustering and classification of early knee osteoarthritis using single-leg standing kinematics.Digital healthArticle
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Authors and funding
23 authors at 20 institutions in 15 countries.
Funding
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Abstract
Background: Early stage of osteoarthritis (OA) is characterized by joint stiffness and pain as well as by subclinical structural changes that may affect cartilage, synovium, and bone. At the moment, the lack of a validated definition of early osteoarthritis (EOA) does not allow to make an early diagnosis and adopt a therapeutic strategy to slow disease progression. Also, no questionnaires are available to evaluate the early stage, and therefore this remains an unmet need. Objective: Therefore, the purpose of the technical experts panel (TEP) of 'International Symposium of intra-articular treatment' (ISIAT) was to create a specific questionnaire to evaluate and monitor the follow-up and clinical progress of patients affected by early knee OA. Design: The items for the Early Osteoarthritis Questionnaire (EOAQ) were identified according to the following steps: items generation, items reduction, and pre-test submission. Methods: During the first step, literature has been reviewed and a comprehensive list of items about pain and function in knee EOA was drafted. Then, during the ISIAT (5th edition 2019), the draft has been discussed by the board, which reformulated, deleted, or subdivided some of the items. After the ISIAT symposium, the draft was submitted to 24 subjects affected by knee OA. A score based on the importance and the frequency was created and the items with a score ⩾0.75 were selected. After intermediate evaluation made by a sample of patients, the second and final version of the questionnaire EOAQ was submitted to the whole board for final analysis and acceptance in a second meeting (29 January 2021). Results: After an exhaustive elaboration, the final version of the questionnaire contains two domains (Clinical Features and Patients Reported Outcome) with respectively 2 and 9 questions, for a total of 11 questions. Questions mainly explored the fields of early symptoms and patients reported outcomes. Marginally, the need of the symptoms treatment and the use of painkillers were investigated. Conclusions: Adoption of diagnostic criteria of early OA is strongly encouraged and a specific questionnaire for the whole management of the clinical features and patients' outcome might really improve the evolution of OA in the early stages of the disease, when the treatment is expected to be more effective.
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