ArticleRadiology. Cardiothoracic imaging2023
Multimodality Imaging in Noonan Syndrome: Case Series of Young Children.
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Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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2 citing papers in PubMed, 1 citations in OpenAlex.
- Targeting Interleukin-8-Mediated Cellular Crosstalk Reverses Hypertrophic Cardiomyopathy and Cardiac Fibrosis in Noonan Syndrome.Circulation · 2026Article
- Cardiac MRI Characteristics of Noonan Syndrome Associated With Hypertrophic Cardiomyopathy and Congenital Heart Disease.Korean journal of radiology · 2025Article
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12 authors at 1 institution in 1 country.
Wenjing Yang *Departments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID https://orcid.org/0000-0002-9929-5480
Yining Wang *Departments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID 0000-0003-3288-7921
Arlene SirajuddinDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID 0000-0001-9183-5983
Jian HeDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID 0000-0001-6899-5145
Weichun WuDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID 0000-0001-8898-6078
Xiaoxin SunDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID 0000-0001-8448-5911
Baiyan ZhuangDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).
Shuang LiDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID 0000-0002-0750-5779
Jing XuDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID 0000-0003-1350-4489
Di ZhouDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).
Shihua ZhaoDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID 0000-0002-7798-0364
Minjie LuDepartments of Magnetic Resonance Imaging (W.Y., Y.W., J.H., B.Z., S.L., J.X., D.Z., S.Z., M.L.), Echocardiography (W.W.), and Nuclear Medicine (X.S.), Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China; Department of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (A.S.); and Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing, China (W.W., X.S., M.L.).ORCID https://orcid.org/0000-0001-8696-318X
Chinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noonan syndrome (NS) is an autosomal dominant disorder characterized by distinctive facial anomalies, growth failure, and a wide spectrum of cardiac abnormalities. Here, the clinical presentation, multimodality imaging characteristics, and management in a case series of four patients with NS are presented. Multimodality imaging showed frequently biventricular hypertrophy accompanied by biventricular outflow tract obstruction and pulmonary stenosis, similar late gadolinium enhancement pattern, and elevation of native T1 and extracellular volume, which may serve as multimodality imaging features in NS to aid in patient diagnosis and treatment.
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CardiacEchocardiographyMR ImagingPediatrics
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