Evidence map›Paper›PMID 36860771›Full record

ArticleJournal of translational autoimmunity2023

Mechanism of action and promising clinical application of melatonin from a dermatological perspective.

Shan Zhang, Xu Yao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational autoimmunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Melatonin in Dermatology.Indian dermatology online journal · 2025
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shan ZhangDepartment of Allergy and Rheumatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Xu YaoDepartment of Allergy and Rheumatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melatonin is the main neuroendocrine product in the pineal gland. Melatonin can regulate circadian rhythm-related physiological processes. Evidence indicates an important role of melatonin in hair follicles, skin, and gut. There appears to be a close association between melatonin and skin disorders. In this review, we focus on the latest research of the biochemical activities of melatonin (especially in the skin) and its promising clinical applications.

Indexed as

5HT, SerotoninAAD, Aromatic amino acid decarboxylaseAANAT/NAT, serotonin-N-acetyltransferase(s)Anti-InflammationAntioxidationCasp-1/3, caspase 1/3CAT, catalaseCOX-2, Cyclooxygenase-2CYP450, cytochrome P450DNCB, 2,4-dinitrochlorobenzeneGPx, Glutathione peroxidaseGSH, GlutathioneHIOMT, 4-hydroxyindole-O-methyl transferaseHO-1, heme oxygenase-1HSP 70, Heat Shock Protein 70IkB, NF-κ-B inhibitorIKK-α, IkB kinase-αIL-1β, interleukin-1 βIL-6, interleukin- 6ImmunoregulationiNOS, Inducible nitric oxide synthaseMelatoninMT1/2, Melatonin receptorMT, MelatoninNF-κB, Nuclear factor kappa-BNQO1, NAD(P), quinone oxidoreductase 1NQO2, NRH, Quinone oxidoreductase 2Nrf2, Nuclear erythroid 2-related factorOncostatic mechanismPEPT1/2, oligopeptide transporter 1/2RNS, Reactive nitrogen speciesROS, Reactive oxygen speciesRZR-α, Retinoid Z receptor αSkin barrierSOD, superoxide dismutaseTPH, tryptophan5-hydroxylase enzymes, including dominant TPH1 and TPH2Trp, Tryptophanγ-GCS, c-glutamylcysteine synthetase

Identifiers

PMID36860771
PMCPMC9969269
OpenAlexW4321379805

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.