SynthesisFrontiers in psychiatry2022
Homocysteine level at the acute stage of ischemic stroke as a biomarker of poststroke depression: A systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Research advances in the association between Irisin and obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Review
- Biochemical role of homocysteine in immune modulation and cytokine dynamics in acute ischemic stroke: Implications for stroke-associated infections.Journal of medical biochemistry · 2025Article
- Influencing factors and predictive models of early post-stroke depression in patients with acute ischemic stroke.BMC neurology · 2025Article
- Application of mindfulness-based stress reduction plan in post-stroke patients with mild depression.Frontiers in neurology · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Studies on the association of homocysteine level with poststroke depression (PSD) have yielded conflicting results. This systematic review and meta-analysis aimed to evaluate the elevated homocysteine level at the acute stage of ischemic stroke in predicting PSD. Methods: Two authors systematically searched articles indexed in PubMed and Embase databases up to 31 January 2022. Studies evaluating the association of homocysteine level with the development of PSD in patients with acute ischemic stroke were selected. Results: A total of 10 studies involving 2,907 patients were identified. The pooled adjusted odds ratio (OR) of PSD was 3.72 [95% confidence intervals (CI) 2.03-6.81] for the top vs. bottom homocysteine level. The value of elevated homocysteine level in predicting PSD was stronger in ≥6-month follow-up (OR 4.81; 95% CI 3.12-7.43) than those in ≤ 3-month follow-up subgroup (OR 3.20; 95% CI 1.29-7.91). Moreover, a per unit increase in homocysteine level conferred a 7% higher risk of PSD. Conclusion: Elevated homocysteine level in the acute stage of ischemic stroke may be an independent predictor of PSD.
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