Evidence map›Paper›PMID 36860666›Full record

ArticleFrontiers in molecular neuroscience2023

Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation.

Vera Rauschenberger, Inken Piro, Vikram Babu Kasaragod, Verena Hörlin, Anna-Lena Eckes, Christoph J Kluck, Hermann Schindelin, Hans-Michael Meinck, Jonathan Wickel, Christian Geis and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Vera RauschenbergerInstitute of Clinical Neurobiology, University Hospital, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Inken PiroDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Vikram Babu KasaragodRudolf Virchow Centre for Integrative and Translational Bioimaging, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Verena HörlinInstitute of Clinical Neurobiology, University Hospital, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Anna-Lena EckesInstitute of Clinical Neurobiology, University Hospital, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Christoph J KluckInstitute of Biochemistry, Emil-Fischer-Center, FAU Erlangen-Nürnberg, Erlangen, Germany.
Hermann SchindelinRudolf Virchow Centre for Integrative and Translational Bioimaging, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Hans-Michael MeinckDepartment of Neurology, University Hospital Heidelberg, Heidelberg, Germany.
Jonathan WickelSection Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany.
Christian GeisSection Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena, Germany.
Erdem TüzünInstitute of Experimental Medicine, Istanbul University, Istanbul, Türkiye.
Kathrin DopplerDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Claudia SommerDepartment of Neurology, University Hospital Würzburg, Würzburg, Germany.
Carmen VillmannInstitute of Clinical Neurobiology, University Hospital, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
University of Würzburg · DEUniversitätsklinikum Würzburg · DEJena University Hospital · DECzech Academy of Sciences, Institute of Experimental Medicine · CZFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycine receptor (GlyR) autoantibodies are associated with stiff-person syndrome and the life-threatening progressive encephalomyelitis with rigidity and myoclonus in children and adults. Patient histories show variability in symptoms and responses to therapeutic treatments. A better understanding of the autoantibody pathology is required to develop improved therapeutic strategies. So far, the underlying molecular pathomechanisms include enhanced receptor internalization and direct receptor blocking altering GlyR function. A common epitope of autoantibodies against the GlyRα1 has been previously defined to residues

Indexed as

adsorptionautoantibodiesextracellular domainglycine receptorglycosylation

Identifiers

PMID36860666
PMCPMC9969106
OpenAlexW4320494333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.