Evidence map›Paper›PMID 36860655›Full record

ArticleCancer research communications2023

Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals

Marni B McClure, Yasunori Kogure, Naser Ansari-Pour, Yuki Saito, Hann-Hsiang Chao, Jonathan Shepherd, Mariko Tabata, Olufunmilayo I Olopade, David C Wedge, Katherine A Hoadley and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancer research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Interferon Epsilon Loss Is Elusive 9p21 Link to Immune-Cold Tumors, Resistant to Immune Checkpoint Therapy, and Endogenous CXCL9/10 Induction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025
    Review
  5. The Hallmarks of Aneuploidy in Cancer and Congenital Syndromes.Annual review of genomics and human genetics · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Marni B McClureDivision of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0002-0807-4368
Yasunori KogureDivision of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0003-1158-5131
Naser Ansari-PourMRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-0908-0484
Yuki SaitoDivision of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0003-2686-9604
Hann-Hsiang ChaoDepartment of Radiation Oncology, Richmond VA Medical Center, Richmond, Virginia.ORCID 0000-0003-1096-0884
Jonathan ShepherdLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-6322-6347
Mariko TabataDivision of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0002-8013-7327
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics & Global Health, University of Chicago School of Medicine, The University of Chicago, Chicago, Illinois.ORCID 0000-0002-9936-1599
David C WedgeManchester Cancer Research Centre, University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-7572-3196
Katherine A HoadleyLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-1216-477X
Charles M Perou *Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-9827-2247
Keisuke Kataoka *Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0002-8263-9902
University of North Carolina at Chapel Hill · USKeio University · JPCancer Research UK Manchester Institute · GBUniversity of Chicago · USUniversity of Oxford · GBUniversity of Tokyo Hospital · JPVirginia Commonwealth University · US

Funding

Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHARLES M PEROU · 1992 to 2026
$59.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Therapeutic Targeting of Breast Cancer Tumor Initiating CellsR01CA148761 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEROU, CHARLES M, ROSEN, JEFFREY MARK · 2010 to 2025
$6.5M
UChicago Interdisciplinary Cancer Health Disparities SPOREP20CA233307 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2018 to 2020
$3.4M
Etiology and Genomics of Breast Cancer Progression in Women of African AncestryR01MD013452 · NIMHD · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG, OLOPADE, OLUFUNMILAYO F. · 2019 to 2023
$2.8M
NCI NIH HHS P20 CA233307NCI NIH HHS P50 CA058223NCI NIH HHS R01 CA148761NIEHS NIH HHS P30 ES010126NIMHD NIH HHS R01 MD013452
6 · The paper itself

Abstract

The hallmark signatures based on gene expression capture core cancer processes. Through a pan-cancer analysis, we describe the overview of hallmark signatures across tumor types/subtypes and reveal significant relationships between these signatures and genetic alterations. Significance: Our data demonstrate that

Indexed as

Breast NeoplasmsCarcinoma, Squamous CellAneuploidyAnimalsFemaleHumansMiceMutationTumor Suppressor Protein p53TP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID36860655
PMCPMC9973382
OpenAlexW4318773754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.