Evidence map›Paper›PMID 36860404›Full record

ArticleJournal of toxicology2023

The Activity of Metalloproteases and Serine Proteases in Various Organs after

Valery Gunas, Oleksandr Maievskyi, Nataliia Raksha, Tetiana Vovk, Oleksiy Savchuk, Serhii Shchypanskyi, Igor Gunas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Valery GunasDepartment of Forensic Medicine and Law, National Pirogov Memorial Medical University, Pyrohova Street 56, Vinnytsya, Ukraine.ORCID https://orcid.org/0000-0002-0778-7737
Oleksandr MaievskyiDepartment of Clinical Medicine, Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv, Hlushkova Avenue 2, Kyiv, Ukraine.ORCID https://orcid.org/0000-0002-9128-1033
Nataliia RakshaDepartment of Biochemistry, Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv, Hlushkova Avenue 2, Kyiv, Ukraine.ORCID https://orcid.org/0000-0001-6654-771X
Tetiana VovkDepartment of Biochemistry, Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv, Hlushkova Avenue 2, Kyiv, Ukraine.ORCID https://orcid.org/0000-0002-0440-8922
Oleksiy SavchukDepartment of Biochemistry, Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv, Hlushkova Avenue 2, Kyiv, Ukraine.ORCID https://orcid.org/0000-0003-3621-6981
Serhii ShchypanskyiDepartment of Biochemistry, Educational and Scientific Center "Institute of Biology and Medicine" of Taras Shevchenko National University of Kyiv, Hlushkova Avenue 2, Kyiv, Ukraine.ORCID https://orcid.org/0000-0002-6259-7784
Igor GunasDepartment of Human Anatomy, National Pirogov Memorial Medical University, Pyrohova Street 56, Vinnytsya, Ukraine.ORCID https://orcid.org/0000-0003-4260-2301
Taras Shevchenko National University of Kyiv · UANational Pirogov Memorial Medical University, Vinnytsya · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Scorpion stings may be life-threatening since their venoms are comprised of a wide range of toxins and other bioactive molecules, such as enzymes. At the same time, scorpion envenomation may increase matrix metalloproteases (MMPs) levels, which enhance proteolytic tissue destruction by venom. However, investigations on the impact of many scorpions' venoms, such as those of Methods and Results: The present study aimed to examine the total proteolysis levels in various organs after Conclusions: Since EDTA presence showed a noticeable decrease in total proteolytic activity level, metalloproteases appeared to play a prominent role in total proteolytic activity. At the same time, MMPs and TIMP-1 levels were increased in all assessed organs, suggesting that

Identifiers

PMID36860404
PMCPMC9970711
OpenAlexW4321365899

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.