Evidence map›Paper›PMID 36859724›Full record

ArticleJournal of cancer research and clinical oncology2023

The investigation of volatile organic compounds in diagnosing (early) esophageal squamous cell carcinoma and gastric adenocarcinoma.

Hang Yang, Chengfang Xiang, Yi Mou, Xinyue Zhou, Wenwen Li, Yixiang Duan, Bing Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hang YangDepartment of Gastroenterology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wu Hou District, Chengdu, 610041, Sichuan, China.
Chengfang XiangCollege of Chemistry, Sichuan University, Chengdu, 610041, China.
Yi MouDepartment of Gastroenterology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wu Hou District, Chengdu, 610041, Sichuan, China.
Xinyue ZhouDepartment of Gastroenterology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wu Hou District, Chengdu, 610041, Sichuan, China.
Wenwen LiWest China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, China.
Yixiang DuanSchool of Mechanical Engineering, Sichuan University, Chengdu, 610064, China.
Bing HuDepartment of Gastroenterology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Wu Hou District, Chengdu, 610041, Sichuan, China. hubingnj@163.com.ORCID http://orcid.org/0000-0002-9898-8656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe diagnosis of upper gastrointestinal cancer (UGIC) and early UGIC is currently based on endoscopy and histopathology. In this study, we aimed to explore whether intraluminal and exhaled volatile organic compounds (VOCs) could be used to diagnose (early) esophageal squamous cell carcinoma (ESCC) and gastric adenocarcinoma (GC).

methodsWe prospectively recruited 259 patients and first collected intraluminal gas simples directly from upper GI tract via our designed device after passing endoscopic biopsy channel and collected exhaled gas samples in pairs.

results509 gas samples were totally collected and VOCs composed by peak compounds detected by gas chromatography-mass spectrometry (GC-MS) were used to train and test Multilayer Perceptron Network (MPN) for discrimination. Intraluminal and exhaled gas had more than 0.95 area under the curve (AUC) to discriminate UGIC (ESCC and GC) and early UGIC from benign control with different VOCs compositions.

conclusionBoth intraluminal and exhaled VOCs had cancer-specific compositions to accurately discriminate early UGIC and UGIC, and the ability of intraluminal VOCs was better than that of exhaled VOCs. These suggested the potential role of VOCs in diagnosing and screening early UGIC and UGIC in the future.

Indexed as

AdenocarcinomaEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaStomach NeoplasmsVolatile Organic CompoundsHumansVolatile Organic CompoundsCancer screeningDiagnosisEsophageal squamous cell carcinomaGastric adenocarcinomaVolatile organic compounds

Identifiers

PMID36859724
PMCPMC11797352

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.