Evidence map›Paper›PMID 36859719›Full record

ReviewNature reviews. Neurology2023

Pain-resolving immune mechanisms in neuropathic pain.

Nathan T Fiore, Sophie R Debs, Jessica P Hayes, Samuel S Duffy, Gila Moalem-Taylor

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07755514 (Translational Analysis of Changes in Inflammatory Biomarkers and Subclinical Cardiac Function Associated With Gabapentin and Pregabalin Use in Patients With Peripheral Neuropathic Pain), which is not on this map. Cited by 138 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 4 pooled it
28.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07755514 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Translational Analysis of Changes in Inflammatory Biomarkers and Subclinical Cardiac Function Associated With Gabapentin and Pregabalin Use in Patients With Peripheral Neuropathic Pain: A Prospective Controlled Cohort Study

Typeobservational_patient_registrySponsorGiresun UniversityRan2026 to 2026Enrolled75ConditionsPeripheral Neuropathic PainArmsGabapentin, Pregabalin
3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 4 syntheses or guidelines pooled it, 164 citations in OpenAlex.

  1. Pooled it
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  4. Neuropathic pain in burn patients - A common problem with little literature: A systematic review.Burns : journal of the International Society for Burn Injuries · 2024
    Pooled it
  5. Article
  6. Glial cells in neuropathic pain.Physiological reviews · 2026
    Review
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nathan T FioreTranslational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, University of New South Wales (UNSW), Sydney, New South Wales, Australia.
Sophie R DebsTranslational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, University of New South Wales (UNSW), Sydney, New South Wales, Australia.
Jessica P HayesTranslational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, University of New South Wales (UNSW), Sydney, New South Wales, Australia.
Samuel S DuffyThe Wollongong Hospital, Illawarra Shoalhaven Local Health District, NSW Health, Wollongong, New South Wales, Australia.
Gila Moalem-TaylorTranslational Neuroscience Facility, Department of Physiology, School of Biomedical Sciences, University of New South Wales (UNSW), Sydney, New South Wales, Australia. gila@unsw.edu.au.ORCID http://orcid.org/0000-0003-3828-9527
UNSW Sydney · AUWollongong Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interactions between the immune and nervous systems are of central importance in neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or disease affecting the somatosensory system. Our understanding of neuroimmune interactions in pain research has advanced considerably. Initially considered as passive bystanders, then as culprits in the pathogenesis of neuropathic pain, immune responses in the nervous system are now established to underpin not only the initiation and progression of pain but also its resolution. Indeed, immune cells and their mediators are well-established promoters of neuroinflammation at each level of the neural pain pathway that contributes to pain hypersensitivity. However, emerging evidence indicates that specific subtypes of immune cells (including antinociceptive macrophages, pain-resolving microglia and T regulatory cells) as well as immunoresolvent molecules and modulators of the gut microbiota-immune system axis can reduce the pain experience and contribute to the resolution of neuropathic pain. This Review provides an overview of the immune mechanisms responsible for the resolution of neuropathic pain, including those involved in innate, adaptive and meningeal immunity as well as interactions with the gut microbiome. Specialized pro-resolving mediators and therapeutic approaches that target these neuroimmune mechanisms are also discussed.

Indexed as

Chronic PainNeuralgiaHumansImmune SystemMicroglia

Identifiers

PMID36859719
OpenAlexW4322735910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.