Evidence map›Paper›PMID 36859627›Full record

ArticleJournal of neurology2023

In vivo characterization of microglia and myelin relation in multiple sclerosis by combined

Valeria T Barletta, Elena Herranz, Constantina Andrada Treaba, Ambica Mehndiratta, Russell Ouellette, Tobias Granberg, Eric C Klawiter, Carolina Ionete, Jacob A Sloane, Caterina Mainero

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Valeria T BarlettaDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.
Elena HerranzDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.
Constantina Andrada TreabaDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.
Ambica MehndirattaDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.
Russell OuelletteDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.
Tobias GranbergDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA.
Eric C KlawiterHarvard Medical School, Boston, MA, USA.
Carolina IoneteUMass Memorial Medical Center, University Campus, Worcester, USA.
Jacob A SloaneDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Caterina MaineroDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Charlestown, Boston, MA, 02129, USA. cmainero@mgh.harvard.edu.
Massachusetts General Hospital · USHarvard University · USAthinoula A. Martinos Center for Biomedical Imaging · USBeth Israel Deaconess Medical Center · USUMass Memorial Medical Center · US

Funding

NIH HHS 1R21NS123419-01NMSS NMSS RG-1802-30468
6 · The paper itself

Abstract

backgroundThe in vivo relation between microglia activation and demyelination in multiple sclerosis is still unclear.

objectiveWe combined

methods

results

conclusionour data suggest an inverse relation of microglia activation and myelination, particularly in perilesional white matter tissue.

Indexed as

Multiple SclerosisWhite MatterBrainHumansMagnetic Resonance ImagingMicrogliaMyelin SheathPositron-Emission TomographyActivated microgliaDemyelinationMRIPETSynthetic MRI

Identifiers

PMID36859627
OpenAlexW4322757377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.