Evidence map›Paper›PMID 36859621›Full record

ArticleParasitology research2023

Antimalarial activity assay of artesunate-3-chloro-4(4-chlorophenoxy) aniline in vitro and in mice models.

Milka Wambui Waithera, Martin Wekesa Sifuna, Daniel Wainaina Kariuki, Johnson Kang'ethe Kinyua, Francis Thuo Kimani, Joseph Kang'ethe Ng'ang'a, Masahiro Takei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Biochemistry research international · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Milka Wambui WaitheraDepartment of Mechanical Engineering, Graduate School of Science and Engineering, Chiba University, 1-33, Inage-Ku, Chiba-Shi, Chiba, 263-8522, Japan.
Martin Wekesa SifunaDepartment of Mechanical Engineering, Graduate School of Science and Engineering, Chiba University, 1-33, Inage-Ku, Chiba-Shi, Chiba, 263-8522, Japan. sifuna@chiba-u.jp.
Daniel Wainaina KariukiDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O Box 62000-00200, Nairobi, Kenya.
Johnson Kang'ethe KinyuaDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O Box 62000-00200, Nairobi, Kenya.
Francis Thuo KimaniCentre for Biotechnology Research and Development, Kenya Medical Research Institute, P.O Box, Nairobi, 54840-00200, Kenya.
Joseph Kang'ethe Ng'ang'aDepartment of Biochemistry, Jomo Kenyatta University of Agriculture and Technology, P.O Box 62000-00200, Nairobi, Kenya.
Masahiro TakeiDepartment of Mechanical Engineering, Graduate School of Science and Engineering, Chiba University, 1-33, Inage-Ku, Chiba-Shi, Chiba, 263-8522, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global spread of multi-drug resistant P. falciparum, P. vivax, and P. malariae strains and absence of long-term effective vaccine makes chemotherapy the mainstay of malaria control strategies in endemic settings. The Mossman's assay and the Organization for Economic Co-operation and Development (OECD), 2001 guideline 423, were used to determine the cytotoxicity and acute oral toxicity of a novel hybrid drug, artesunate-3-Chloro-4(4-chlorophenoxy) aniline (ATSA), in vitro and in vivo, respectively. A modified Desjardins method was used to screen for antiplasmodial activity using P. falciparum (3D

Indexed as

AntimalarialsMalariaMalaria, FalciparumMalaria, VivaxAniline CompoundsAnimalsArtesunateHumansLumefantrineMicePlasmodium bergheiPlasmodium falciparumanilineAniline CompoundsAntimalarialsArtesunateLumefantrineADMET profilesAntimalariaArtesunate-3-chloro-4-(4-chlorophenoxy) anilineHybrid drugs

Identifiers

PMID36859621
PMCPMC9977633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.