Evidence map›Paper›PMID 36859574›Full record

ArticleFish physiology and biochemistry2023

Functional exploration of SNP mutations in HIF2αb gene correlated with hypoxia tolerance in blunt snout bream (Megalobrama amblycephala).

Shan-Shan Zhao, Xiao-Lei Su, Hui-Qi Yang, Guo-Dong Zheng, Shu-Ming Zou

Abstract read
PubMed Publisher
In one paragraph

Article in Fish physiology and biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Shan-Shan Zhao *National Demonstration Center for Experimental Fisheries Science Education, Genetics and Breeding Center for Blunt Snout Bream, Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Ocean University, Shanghai, 201306, China.
Xiao-Lei Su *National Demonstration Center for Experimental Fisheries Science Education, Genetics and Breeding Center for Blunt Snout Bream, Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Ocean University, Shanghai, 201306, China.
Hui-Qi YangNational Demonstration Center for Experimental Fisheries Science Education, Genetics and Breeding Center for Blunt Snout Bream, Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Ocean University, Shanghai, 201306, China.
Guo-Dong ZhengNational Demonstration Center for Experimental Fisheries Science Education, Genetics and Breeding Center for Blunt Snout Bream, Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Ocean University, Shanghai, 201306, China. gdzheng@shou.edu.cn.
Shu-Ming ZouNational Demonstration Center for Experimental Fisheries Science Education, Genetics and Breeding Center for Blunt Snout Bream, Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture, Shanghai Ocean University, Shanghai, 201306, China. smzou@shou.edu.cn.ORCID http://orcid.org/0000-0003-3522-8390
Ministry of Agriculture · CAShanghai Ocean University · CNZhejiang Ocean University · CN

Funding

the Key Projects of Revitalizing Agriculture through Science and Technology from Shanghai Agricultural and Rural Commission 022-02-08-00-12-F01179the National Key Research and Development Plan Program 2022YFD2400602the National Natural Science Foundation of China 32273100the Research on the Frontier of Aquatic Peak-Innovation Strategy Source A1-3201-21-0004-1
6 · The paper itself

Abstract

Blunt snout bream (Megalobrama amblycephala) is sensitive to hypoxia environment. Hypoxia-inducible factor (HIF) is the most critical factor in the HIF pathway, which strictly regulates the hypoxia stress process of fish. In this study, we found six hifα genes in blunt snout bream that demonstrated different expressions under hypoxia conditions. In HEK293T cells, all six hifαs were detected to activate the HRE region by luciferase reporter assay. More importantly, we identified two linkage-disequilibrium SNP sites at exon 203 and 752 of the hif2αb gene in blunt snout bream. Haplotype II (A

Indexed as

CyprinidaeCypriniformesAnimalsFish ProteinsHEK293 CellsHumansHypoxiaMutationFish ProteinsHIFαsHypoxiaMegalobrama amblycephalaSNP mutation

Identifiers

PMID36859574
OpenAlexW4322754680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.