Evidence map›Paper›PMID 36859550›Full record

ArticleNature2023

H3K4me3 regulates RNA polymerase II promoter-proximal pause-release.

Hua Wang, Zheng Fan, Pavel V Shliaha, Matthew Miele, Ronald C Hendrickson, Xuejun Jiang, Kristian Helin

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 266 papers.

0numbers the graph read from it
0cells of the map it votes in
266citing papers in PubMed
65.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

266 citing papers in PubMed, 408 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. The molecular basis of transcription initiation by RNA polymerase II.Nature reviews. Molecular cell biology · 2026
    Review
  11. Review
  12. Epigenetic regulation of transgenes.Journal of biotechnology · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

206 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Hua WangCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zheng FanThe Institute of Cancer Research, London, United Kingdom.ORCID http://orcid.org/0000-0003-1934-2521
Pavel V ShliahaMicrochemistry and Proteomics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Matthew MieleMicrochemistry and Proteomics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7495-2133
Ronald C HendricksonMicrochemistry and Proteomics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Xuejun JiangCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8670-3828
Kristian HelinCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. kristian.helin@icr.ac.uk.ORCID http://orcid.org/0000-0003-1975-6097
Memorial Sloan Kettering Cancer Center · USUniversity of Copenhagen · DK

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Ferroptosis, Cellular Metabolism, and CancerR01CA204232 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JIANG, XUEJUN · 2017 to 2025
$4.1M
Mechanisms and Function of Autophagy in CancerR01CA166413 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JIANG, XUEJUN · 2013 to 2023
$3.9M
Ferroptosis and Cancer Cell SignalingR01CA258622 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Xuejun Jiang · 2022 to 2026
$2.2M
LTQ-ORBITRAP VELOS Tandem Mass SpectrometerS10OD010598 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI HENDRICKSON, RONALD CHARLES · 2012 to 2012
$460k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA166413NCI NIH HHS R01 CA204232NCI NIH HHS R01 CA258622NIH HHS S10 OD010598
6 · The paper itself

Abstract

Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites and has been proposed to regulate transcription initiation

Indexed as

HistonesMouse Embryonic Stem CellsPromoter Regions, GeneticRNA Polymerase IITranscription Elongation, GeneticTranscription Termination, GeneticAnimalsEndoribonucleasesGene Expression RegulationHistone DemethylasesMethylationMiceEndoribonucleasesHistone Demethylaseshistone H3 trimethyl Lys4HistonesInts11 protein, mouseRNA Polymerase II

Identifiers

PMID36859550
PMCPMC9995272
OpenAlexW4322738638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.