ArticleNature2023
Blebs promote cell survival by assembling oncogenic signalling hubs.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
29.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- The romantic history of signaling pathway discovery in cell death: an updated review.Molecular and cellular biochemistry · 2024Pooled it
- Multimodal Biophysical Analysis of Morpho-Phenotypic and Morpho-Functional Dynamics in Normal and Cancer Spheroids within Engineered Microenvironments.Chemical & biomedical imaging · 2026Article
- Epithelial-mesenchymal transition in carcinoma: navigating phenotypic states to target resistance and metastasis.Cancer metastasis reviews · 2026Review
- Data modeling the interplay between single-cell shape, single-cell protein expression, and tissue state.Cell reports methods · 2026Article
- MIR133B-SEPT9 axis suppresses colorectal cancer progression by inhibiting β-catenin-mediated EMT signaling and is associated with poor prognosis.Molecular medicine (Cambridge, Mass.) · 2026Article
- CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration.Nature cell biology · 2026Article
- Mechanisms of active wetting and fluidification in epithelial cell collectives.Nature materials · 2026Article
- Natural killer cell-mediated immunosurveillance modulates liver cancer evolution through cancer stemness enhancement and lipid metabolism reprogramming.Nature communications · 2026Article
- Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.Research square · 2026Article
- Dynamic blebbing and absence of organelle transfer during mouse oocyte formation.The EMBO journal · 2026Article
- Bleb expansion requires transient membrane invaginations that sequester curvature-preferring proteins.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Amoeboid cancer cells at a glance.Journal of cell science · 2026Review
- Diverse roles of SERPINE1 in regulating cellular proliferation and invasion.International journal of oncology · 2026Article
- Local RhoA activation induces anillin-independent septin recruitment in interphase cells.Molecular biology of the cell · 2026Article
- Modulation of Oncogenic KRAS Signaling by Branched Actin-driven Cell Membrane Protrusions.bioRxiv : the preprint server for biology · 2026Article
- Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death.Cytoskeleton (Hoboken, N.J.) · 2026Article
- CaMKII nucleates an osmotic protein supercomplex to induce cellular bleb expansion.The EMBO journal · 2026Article
- Anoikis-Related Genes Signature Contributes to Predicting Prognosis and Response to Immunotherapy in Lung Squamous Cell Carcinoma.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- WWP1 gain-of-function drives developmental anoikis through TGFβ pathway during neurodevelopment.Cell death discovery · 2026Article
- Membrane Curvature Activates Src kinase and Promotes Metastatic Cancer Cell Survival.bioRxiv : the preprint server for biology · 2026Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Andrew D WeemsLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. Andrew.Weems@UTSouthwestern.edu.
Erik S WelfLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5968-3323
Meghan K DriscollLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-7991-5614
Felix Y ZhouLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Hanieh Mazloom-FarsibafLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Bo-Jui ChangLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5513-7106
Vasanth S MuraliLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1782-7034
Gabriel M GihanaLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-5443-4440
Byron G WeissLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4396-5411
Joseph ChiLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Divya RajendranLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Kevin M DeanLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-0839-2320
Reto FiolkaLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA.
Gaudenz DanuserLyda Hill Department of Bioinformatics, UT Southwestern Medical Center, Dallas, TX, USA. Gaudenz.Danuser@UTSouthwestern.edu.ORCID 0000-0001-8583-2014
Southwestern Medical Center · USRegeneron (United States) · USUniversity of Minnesota · US
Funding
Functional causality in regulating cell morphogenesisR35GM136428 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DANUSER, GAUDENZ · 2020 to 2024
$4.1MTransformative microscopes to image across spatiotemporal scalesR35GM133522 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Reto Paul Fiolka · 2019 to 2026
$3.1MMultiscale microscope for 3D cancer imaging in model organisms and organoidsR33CA235254 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI FIOLKA, RETO PAUL · 2019 to 2021
$930kFormation and function of lamellipodial morphology in 3D microenvironmentsK99GM123221 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI DRISCOLL, MEGHAN KATRIEN · 2018 to 2019
$180kNCI NIH HHS R33 CA235254NIGMS NIH HHS K99 GM123221NIGMS NIH HHS R35 GM133522NIGMS NIH HHS R35 GM136428
Abstract
Most human cells require anchorage for survival. Cell-substrate adhesion activates diverse signalling pathways, without which cells undergo anoikis-a form of programmed cell death
Indexed as
AnoikisCarcinogenesisCell Surface ExtensionsCell SurvivalMelanomaSignal TransductionCell AdhesionCell ShapeExtracellular Signal-Regulated MAP KinasesFibroblastsGTP PhosphohydrolasesHumansImaging, Three-DimensionalMembrane ProteinsMitogen-Activated Protein Kinase KinasesMutationBRAF protein, humanExtracellular Signal-Regulated MAP KinasesGTP PhosphohydrolasesMembrane ProteinsMitogen-Activated Protein Kinase KinasesNRAS protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafSeptins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.