ArticleNature2023
Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion.
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In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
29.3field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
112 citing papers in PubMed, 197 citations in OpenAlex.
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- Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses.bioRxiv : the preprint server for biology · 2026Article
- Bladder mucosal afferents detect UTI and aid pathogen clearance.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Infection control in the brain and the eye.Acta ophthalmologica · 2026Review
- Metastatic Cancers Exploit Vagal Sensory Neurons and Neural Repair Programs to Colonize New Tissues.Research square · 2026Article
- A delayed endothelial-glial mechanism for CGRP-induced migraine.The journal of headache and pain · 2026Review
- Oral Microbiota and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study Based on East Asian Ethnicity.Health science reports · 2026Article
- Wired for immunity: neuroimmune control of the lung by sensory neurons.Nature reviews. Neuroscience · 2026Review
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- Association of inflammatory biomarkers during pregnancy and the postpartum period with the risk of postpartum anxiety symptoms.Brain, behavior, & immunity - health · 2026Article
- Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion.Nature communications · 2026Article
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- Pathogens of the Human Central Nervous System- the Major Bacterial Pathogens.Molecular neurobiology · 2026Review
- Hallmarks of headache disorders: part 5 - secondary headaches.The journal of headache and pain · 2026Review
- Crotonylation driving Streptococcus pneumoniae adaption and virulence.Journal of advanced research · 2026Article
- Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins.Nature neuroscience · 2026Article
- Meningeal neuropeptide and neuroimmune interactions in the context of migraine.The journal of headache and pain · 2026Review
- Evaluation of safety and efficacy of an auxotrophic aroA mutant live attenuated vaccine against piscine Streptococcus agalactiae infection.NPJ vaccines · 2026Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Felipe A Pinho-RibeiroDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Liwen DengDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Dylan V NeelDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6964-9842
Ozge ErdoganDepartment of Restorative Dentistry and Biomaterial Sciences, Harvard School of Dental Medicine, Boston, MA, USA.
Himanish BasuDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8236-1157
Daping YangDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Samantha ChoiDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Alec J WalkerF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Simone Carneiro-NascimentoDepartments of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-6141-6080
Kathleen HeDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Glendon WuDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Beth StevensF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-4226-1201
Kelly S DoranDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dan LevyHarvard Medical School, Boston, MA, USA.
Isaac M ChiuDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Isaac_chiu@hms.harvard.edu.ORCID 0000-0002-0723-4841
Harvard University · USBeth Israel Deaconess Medical Center · USBroad Institute · USUniversity of Colorado Anschutz Medical Campus · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MRegulation of Synaptic engulfment by human C4P50MH112491 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI Michael Craig Carroll, Beth Ann Stevens · 2017 to 2026
$29.5MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4MStaphylococcus aureus induced itch and neuro-immune signaling in skin infectionsR01AI168005 · NIAID · HARVARD MEDICAL SCHOOL · PI Isaac Ming-Cheng Chiu, ALEXANDER R HORSWILL · 2022 to 2026
$3.7MPain and Neuro-immune Signaling in S. pyogenes pathogenesisR01AI130019 · NIAID · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG, WESSELS, MICHAEL R · 2017 to 2021
$3.2MMECHANISMS OF CSD-EVOKED PERSISTENT ACTIVATION OF MENINGEAL NOCICEPTORSR01NS078263 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LEVY, DAN · 2013 to 2022
$3.1MCortical-Meningeal Interactions Underlying Migraine HeadacheR01NS115972 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI DAN LEVY · 2021 to 2026
$2.3MNociceptor neuron regulation of gastrointestinal barrier protection and host defenseR01DK127257 · NIDDK · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2021 to 2024
$2.2MModulation of Blood-Brain Barrier Defense and Dysfunction during Bacterial MeningitisR01NS116716 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2020 to 2024
$1.9MNIAID NIH HHS R01 AI130019NIAID NIH HHS R01AI130019NIAID NIH HHS R01 AI168005NICHD NIH HHS P50 HD105351NIDDK NIH HHS R01 DK127257NIDDK NIH HHS R01DK127257NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIMH NIH HHS P50 MH112491NIMH NIH HHS P50MH112491NINDS NIH HHS 2R01NS078263NINDS NIH HHS 5R01NS115972NINDS NIH HHS R01 NS078263NINDS NIH HHS R01 NS115972NINDS NIH HHS R01 NS116716NINDS NIH HHS R01NS116716
Abstract
The meninges are densely innervated by nociceptive sensory neurons that mediate pain and headache
Indexed as
BrainMeningesMeningitis, BacterialNeuroimmunomodulationCalcitonin Gene-Related PeptideHumansMacrophagesNAV1.8 Voltage-Gated Sodium ChannelNociceptorsPainReceptor Activity-Modifying Protein 1Streptococcus agalactiaeStreptococcus pneumoniaeCalcitonin Gene-Related PeptideNAV1.8 Voltage-Gated Sodium ChannelReceptor Activity-Modifying Protein 1
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.