Evidence map›Paper›PMID 36859542›Full record

ArticleNature2023

Coordination of bacterial cell wall and outer membrane biosynthesis.

Katherine R Hummels, Samuel P Berry, Zhaoqi Li, Atsushi Taguchi, Joseph K Min, Suzanne Walker, Debora S Marks, Thomas G Bernhardt

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. LPS in gram-negative bacterial growth and physiology: outside but fully integrated.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Materials today. Bio · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katherine R HummelsDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6386-8419
Samuel P BerryDepartment of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3480-5988
Zhaoqi LiDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Atsushi TaguchiDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4962-0393
Joseph K MinDepartment of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Suzanne WalkerDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0545-914X
Debora S MarksDepartment of Systems Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9388-2281
Thomas G BernhardtDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. thomas_bernhardt@hms.harvard.edu.ORCID http://orcid.org/0000-0003-3566-7756

Funding

MOLECULAR BIOPHYSICS TRAINING GRANTT32GM008313 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MURTHY, VENKATESH N · 1989 to 2023
$14.6M
Project 3: Defining and defeating the mechanisms of outer membrane biogenesis in Gram-negative bacteriaU19AI158028 · NIAID · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2022 to 2025
$10.1M
Peptidoglycan Biogenesis in Escherichia ColiR01AI083365 · NIAID · HARVARD MEDICAL SCHOOL · PI Thomas G Bernhardt · 2010 to 2026
$8.3M
Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Investigating the regulation of outer membrane homeostasis in Pseudomonas aeruginosaF32AI164630 · NIAID · HARVARD MEDICAL SCHOOL · PI HUMMELS, KATHERINE RUTH · 2021 to 2023
$131k
NIAID NIH HHS F32 AI164630NIAID NIH HHS R01 AI083365NIAID NIH HHS R01 AI148752NIAID NIH HHS U19 AI158028NIGMS NIH HHS R01 GM129325NIGMS NIH HHS T32 GM008313
6 · The paper itself

Abstract

Gram-negative bacteria surround their cytoplasmic membrane with a peptidoglycan (PG) cell wall and an outer membrane (OM) with an outer leaflet composed of lipopolysaccharide (LPS)

Indexed as

Bacterial Outer MembraneCell WallPseudomonas aeruginosaAlkyl and Aryl TransferasesAmidohydrolasesLipopolysaccharidesPeptidoglycanAlkyl and Aryl TransferasesAmidohydrolasesLipopolysaccharidesLpxC deacetylase, PseudomonasPeptidoglycanUDP-N-acetylglucosamine 1-carboxyvinyltransferase

Identifiers

PMID36859542
PMCPMC9995270

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.