Evidence map›Paper›PMID 36859464›Full record

ArticleScientific reports2023

A portable, programmable, multichannel stimulator with high compliance voltage for noninvasive neural stimulation of motor and sensory nerves in humans.

Marshall A Trout, Abigail T Harrison, Mark R Brinton, Jacob A George

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. An Intuitive, Bidirectional, and Adaptive Functional Electrical Stimulation System for Hand Rehabilitation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
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  4. Reinforcement Learning Agent Trained as FES Controller in Modified Xia-Law Simulation Robustly Controls Grip Force.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  5. Effect of Wrist Posture on the Intensity, Size, and Location of Hand Sensations Evoked by Transcutaneous Nerve Stimulation at the Wrist.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  6. Cold Tissue Temperature Decreases Electrocutaneous Sensory Perception and Discriminability.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  7. Voice-Controlled Dual-Site Functional Electrical Stimulation Enables Tenodesis Grasping.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marshall A TroutDepartment of Electrical and Computer Engineering, University of Utah, Salt Lake City, USA. marshall.trout@utah.edu.
Abigail T HarrisonDepartment of Biomedical Engineering, University of Utah, Salt Lake City, USA.
Mark R BrintonDepartment of Engineering and Physics, Elizabethtown College, Elizabethtown, USA.
Jacob A GeorgeDepartment of Electrical and Computer Engineering, University of Utah, Salt Lake City, USA. jacob.george@utah.edu.
University of Utah · USElizabethtown College · US

Funding

Patient-centered rehabilitation and dexterous assistive devices for stroke patients using bionic exoskeletons controlled by non-invasive electromyographyDP5OD029571 · OD · UNIVERSITY OF UTAH · PI GEORGE, JACOB ANTHONY · 2020 to 2024
$2.1M
NIH HHS DP5 OD029571NIH HHS DP5OD029571
6 · The paper itself

Abstract

Most neural stimulators do not have a high enough compliance voltage to pass current through the skin. The few stimulators that meet the high compliance voltage necessary for transcutaneous stimulation are typically large benchtop units that are not portable, and the stimulation waveforms cannot be readily customized. To address this, we present the design and validation of a portable, programmable, multichannel, noninvasive neural stimulator that can generate three custom bipolar waveforms at ± 150 V with microsecond temporal resolution. The design is low-cost, open-source, and validated on the benchtop and with a healthy population to demonstrate its functionality for sensory and motor stimulation. Sensory stimulation included electrocutaneous stimulation targeting cutaneous mechanoreceptors at the surface of the skin and transcutaneous nerve stimulation targeting the median nerve at the wrist. Both electrocutaneous stimulation on the hand and transcutaneous stimulation at the wrist can elicit isolated tactile percepts on the hand but changes in pulse frequency are more discriminable for electrocutaneous stimulation. Also, neuromuscular electrical stimulation of the flexor digiti profundus is evoked by applying electrical stimulation directly above the muscle in the forearm and to the median and ulnar nerves in the upper arm. Muscle and nerve stimulation evoked similar grip forces and force rise times, but nerve stimulation had a significantly slower fatigue rate. The development and validation of this noninvasive stimulator and direct comparison of common sensory and motor stimulation targets in a human population constitute an important step towards more widespread use and accessibility of neural stimulation for education and research.

Indexed as

Upper ExtremityWristAfferent PathwaysHumansMedian NerveUlnar Nerve

Identifiers

PMID36859464
PMCPMC9977866
OpenAlexW4322739046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.