Trial reportPediatric research2023
How well does neonatal neuroimaging correlate with neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy?
Trial report in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- MRI scoring systems in neonatal encephalopathy and neurodevelopmental outcomes: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Clinical Trial.JAMA network open · 2023Trial
- Novel neonatal hypoxic-ischemic model demonstrates glial activation and memory deficits without neuronal loss.Pediatric research · 2026Article
- Magnetic Resonance Imaging of the Neonatal Brain: Modalities, Scoring Systems, and Clinical Applications.Bioengineering (Basel, Switzerland) · 2026Review
- Prognostic value of Cranial Ultrasound combined with Serum Neuron-Specific Enolase and Creatine Kinase-MB Isoenzyme Measurement in Neonatal Hypoxic-Ischemic Encephalopathy.Pakistan journal of medical sciences · 2026Article
- Optimizing therapeutic hypothermia conditions in a translational preclinical model of neonatal hypoxia-ischemia in rats.Pediatric research · 2026Article
- Bridging the gap: Translating fetal, infant, and toddler neuroimaging insights into clinical practice.Developmental cognitive neuroscience · 2026Review
- Magnetic resonance imaging and spectroscopy in neonatal encephalopathy: current consensus position and future opportunities.Pediatric research · 2026Review
- Neonatal encephalopathy and 3 year outcomes: a French population-based cohort.Pediatric research · 2026Article
- Predictors of adverse outcome in infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: a real-world cohort study.BMC pediatrics · 2026Article
- Sonographic Brain Volume Growth Trajectories in VLBW and Clinical Determinants-Data from the NeoNEVS Project.Children (Basel, Switzerland) · 2026Article
- Association of the neonatal sequential organ failure assessment score with neurological outcomes in infants diagnosed with hypoxic-ischemic encephalopathy.Frontiers in pediatrics · 2026Article
- Neurodevelopmental disorders in children: the role of MRI in early detection and intervention planning.Frontiers in neuroscience · 2026Review
- The relationship between sonographically assessed volumetric brain development in VLBW preterm infants and neurodevelopmental outcome at 2 years of age-data from the NeoNEVS project.Frontiers in pediatrics · 2026Article
- Combined model of radiomics and clinical features for predicting prognosis of term neonatal hypoxic-ischemic encephalopathy after one year: an exploratory study.BMC medical imaging · 2025Article
- Emerging modalities for neuroprognostication in neonatal encephalopathy: harnessing the potential of artificial intelligence.Pediatric research · 2025Review
- Beyond brain injury: rethinking neurodevelopment in neonatal encephalopathy.Pediatric research · 2025Article
- Shifting outlooks after neonatal encephalopathy in the era of therapeutic hypothermia.Pediatric research · 2025Review
- Neuroprognostication in neonatal encephalopathy due to presumed hypoxic-ischemic encephalopathy.Pediatric research · 2025Review
- Neonatal hypoxic-ischaemic encephalopathy and therapeutic hypothermia: prognostic value of intra-axial haemorrhage.European journal of pediatrics · 2025Observational
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundIn newborns with hypoxic-ischemic encephalopathy (HIE), the correlation between neonatal neuroimaging and the degree of neurodevelopmental impairment (NDI) is unclear.
methodsInfants with HIE enrolled in a randomized controlled trial underwent neonatal MRI/MR spectroscopy (MRS) using a harmonized protocol at 4-6 days of age. The severity of brain injury was measured with a validated scoring system. Using proportional odds regression, we calculated adjusted odds ratios (aOR) for the associations between MRI/MRS measures of injury and primary ordinal outcome (i.e., normal, mild NDI, moderate NDI, severe NDI, or death) at age 2 years.
resultsOf 451 infants with MRI/MRS at a median age of 5 days (IQR 4.5-5.8), outcomes were normal (51%); mild (12%), moderate (14%), severe NDI (13%); or death (9%). MRI injury score (aOR 1.06, 95% CI 1.05, 1.07), severe brain injury (aOR 39.6, 95% CI 16.4, 95.6), and MRS lactate/n-acetylaspartate (NAA) ratio (aOR 1.6, 95% CI 1.4,1.8) were associated with worse primary outcomes. Infants with mild/moderate MRI brain injury had similar BSID-III cognitive, language, and motor scores as infants with no injury.
conclusionIn the absence of severe injury, brain MRI/MRS does not accurately discriminate the degree of NDI. Given diagnostic uncertainty, families need to be counseled regarding a range of possible neurodevelopmental outcomes. IMPACT: Half of all infants with hypoxic-ischemic encephalopathy (HIE) enrolled in a large clinical trial either died or had neurodevelopmental impairment at age 2 years despite receiving therapeutic hypothermia. Severe brain injury and a global pattern of brain injury on MRI were both strongly associated with death or neurodevelopmental impairment. Infants with mild or moderate brain injury had similar mean BSID-III cognitive, language, and motor scores as infants with no brain injury on MRI. Given the prognostic uncertainty of brain MRI among infants with less severe degrees of brain injury, families should be counseled regarding a range of possible neurodevelopmental outcomes.
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Registered trials
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