Evidence map›Paper›PMID 36859392›Full record

ArticleNature communications2023

Extracting particle size distribution from laser speckle with a physics-enhanced autocorrelation-based estimator (PEACE).

Qihang Zhang, Janaka C Gamekkanda, Ajinkya Pandit, Wenlong Tang, Charles Papageorgiou, Chris Mitchell, Yihui Yang, Michael Schwaerzler, Tolutola Oyetunde, Richard D Braatz and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Qihang ZhangDepartment of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-5018-8310
Janaka C GamekkandaDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0003-1456-7609
Ajinkya PanditDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0002-2709-7928
Wenlong TangData Sciences Institutes, Takeda Pharmaceuticals International Co, 650 E Kendall St, Cambridge, MA, 02142, USA.
Charles PapageorgiouProcess Chemistry Development, Takeda Pharmaceuticals International Co, 40 Landsdowne St, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0001-7959-6289
Chris MitchellProcess Chemistry Development, Takeda Pharmaceuticals International Co, 40 Landsdowne St, Cambridge, MA, 02139, USA.
Yihui YangProcess Chemistry Development, Takeda Pharmaceuticals International Co, 40 Landsdowne St, Cambridge, MA, 02139, USA.
Michael SchwaerzlerInnovation and Technology Sciences, Takeda Pharmaceutical Company Limited, 200 Shire Way, Lexington, MA, 02421, USA.ORCID http://orcid.org/0000-0002-3240-0856
Tolutola OyetundeInnovation and Technology Sciences, Takeda Pharmaceutical Company Limited, 200 Shire Way, Lexington, MA, 02421, USA.
Richard D BraatzDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0003-4304-3484
Allan S MyersonDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID http://orcid.org/0000-0002-7468-8093
George BarbastathisDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. gbarb@mit.edu.ORCID http://orcid.org/0000-0002-4140-1404
Takeda (United States) · USMassachusetts Institute of Technology · USSingapore-MIT Alliance for Research and Technology · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracting quantitative information about highly scattering surfaces from an imaging system is challenging because the phase of the scattered light undergoes multiple folds upon propagation, resulting in complex speckle patterns. One specific application is the drying of wet powders in the pharmaceutical industry, where quantifying the particle size distribution (PSD) is of particular interest. A non-invasive and real-time monitoring probe in the drying process is required, but there is no suitable candidate for this purpose. In this report, we develop a theoretical relationship from the PSD to the speckle image and describe a physics-enhanced autocorrelation-based estimator (PEACE) machine learning algorithm for speckle analysis to measure the PSD of a powder surface. This method solves both the forward and inverse problems together and enjoys increased interpretability, since the machine learning approximator is regularized by the physical law.

Identifiers

PMID36859392
PMCPMC9977959
OpenAlexW4322735168

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.