ArticleBMC medicine2023
Influence of poor sleep on cardiovascular disease-free life expectancy: a multi-resource-based population cohort study.
Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials.BMC medicine · 2026Pooled it
- Sex Differences in Insomnia and Circadian Rhythm Disorders: A Systematic Review.Medicina (Kaunas, Lithuania) · 2024Pooled it
- Midlife Sleep and Circadian Health: Implications for Cardiovascular and Cognitive Outcomes.Obstetrics and gynecology clinics of North America · 2026Review
- Could behaviour change interventions be incorporated into cardiac rehabilitation programmes for insomnia and poor sleep quality management? A scoping review.Sleep & breathing = Schlaf & Atmung · 2026Article
- A Theory-Based Nursing Scale for Measuring the Impact of Sleep Disturbance on Quality of Life.Nursing open · 2026Article
- The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics.BMC medicine · 2026Article
- Association of cardiometabolic index and glomerular filtration rate with sleep disorders: NHANES 2005-2020.Journal of health, population, and nutrition · 2025Article
- The impact of emotional management ability on sleep quality of university students: chain mediation of physical exercise and electronic health literacy.BMC psychology · 2025Article
- Menopause-Related Changes in Sleep and the Associations with Cardiometabolic Health: A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- A chain mediation model for physical exercise and sleep quality.Scientific reports · 2025Article
- Prevalence of high 10-year cardiovascular risk among the general population in Malaysia and the associated factors: a nationwide community-based study in 2023.BMC public health · 2025Article
- Social media addiction as the central mediating variable to explore the mechanism between physical exercise and sleep quality.Scientific reports · 2025Article
- Adverse effects of obesity on overall health, quality of life, and related physical health metrics: A cross-sectional and longitudinal study from the All of Us Research Program.Journal of internal medicine · 2025Article
- Proposed domains of postpartum sleep: a concept elicitation study using qualitative interviews.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Research on the effect of TMS on insomnia patients: EEG changes and prognostic modeling.Frontiers in neuroscience · 2025Article
- Cancer Diagnosis, Physical Activity, and Heart Disease Risk.JACC. CardioOncology · 2024Article
- Sleep duration and mortality in patients with chronic noncommunicable disease: a population-based cohort study.Environmental health and preventive medicine · 2024Article
- Relation of Sleep Quality to a Panel of Plasma Cardiometabolic Markers in Airline Pilots: A Cross-Sectional Study.Cureus · 2024Article
- Unveiling the sleep-cardiovascular connection: Novel perspectives and interventions-A narrative review.Health science reports · 2023Article
- Extrinsic and intrinsic modulators of inflammation-resolution signaling in heart failure.American journal of physiology. Heart and circulatory physiology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe complexity of sleep hinders the formulation of sleep guidelines. Recent studies suggest that different unhealthy sleep characteristics jointly increase the risks for cardiovascular disease (CVD). This study aimed to estimate the differences in CVD-free life expectancy between people with different sleep profiles.
methodsWe included 308,683 middle-aged adults from the UK Biobank among whom 140,181 had primary care data linkage. We used an established composite sleep score comprising self-reported chronotype, duration, insomnia complaints, snoring, and daytime sleepiness to derive three sleep categories: poor, intermediate, and healthy. We also identified three clinical sleep disorders captured by primary care and inpatient records within 2 years before enrollment in the cohort: insomnia, sleep-related breathing disorders, and other sleep disorders. We estimated sex-specific CVD-free life expectancy with three-state Markov models conditioning on survival at age 40 across different sleep profiles and clinical disorders.
resultsWe observed a gradual loss in CVD-free life expectancy toward poor sleep such as, compared with healthy sleepers, poor sleepers lost 1.80 [95% CI 0.96-2.75] and 2.31 [1.46-3.29] CVD-free years in females and males, respectively, while intermediate sleepers lost 0.48 [0.41-0.55] and 0.55 [0.49-0.61] years. Among men, those with clinical insomnia or sleep-related breathing disorders lost CVD-free life by 3.84 [0.61-8.59] or 6.73 [5.31-8.48] years, respectively. Among women, sleep-related breathing disorders or other sleep disorders were associated with 7.32 [5.33-10.34] or 1.43 [0.20-3.29] years lost, respectively.
conclusionsBoth self-reported and doctor-diagnosed poor sleep are negatively associated with CVD-free life, especially pronounced in participants with sleep-related breathing disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.