ArticleJournal of Korean Neurosurgical Society2023
Perspectives : Understanding the Pathophysiology of Intraventricular Hemorrhage in Preterm Infants and Considering of the Future Direction for Treatment.
Article in Journal of Korean Neurosurgical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Pooled prevalence and predictors of intraventricular hemorrhage (IVH) in preterm neonates (28-34 weeks) in Africa: a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Rapid Improvement in Cerebral Palsy Following Treatment With Perispinal Etanercept: A Case Report.Cureus · 2026Article
- Iron-driven secondary injury after intracranial hemorrhage: mitochondrial dysfunction and ferroptosis.Frontiers in neuroscience · 2026Review
- Advances in temporizing treatment strategies and associated complications for posthemorrhagic hydrocephalus in preterm infants.Frontiers in pediatrics · 2026Review
- Early-onset preeclampsia exposure and hospital outcomes of very preterm infants: a retrospective analysis of feeding intolerance and hospital morbidities.Frontiers in pediatrics · 2026Article
- Feasibility Study on Inflammasome Proteins as Biomarkers in the Cerebrospinal Fluid of Pediatric Patients with Hydrocephalus Due to Intraventricular Hemorrhage.Biomolecules · 2025Article
- Parenting experiences of informal caregivers of preterm infants during the first 2 years of life at corrected age: a qualitative systematic review protocol.JBI evidence synthesis · 2025Article
- Variability in the Deformability of Red Blood Cells: Application to Treating Premature Newborns with Blood Transfusion.International journal of molecular sciences · 2025Article
- Paediatric cranial ultrasound: assessment of the preterm brain.Insights into imaging · 2025Article
- The Early Hematological Profile and Its Variations: A Useful Tool in the Prediction of Intraventricular Hemorrhage in Extremely Preterm Infants.Medicina (Kaunas, Lithuania) · 2024Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Remarkable advances in neonatal care have significantly improved the survival of extremely low birth weight infants in recent years. However, intraventricular hemorrhage (IVH) continues to be a major complication in preterm infants, leading to a high incidence of cerebral palsy and cognitive impairment. IVH is primarily caused by disruption of the fragile vascular network of the subependymal germinal matrix, and subsequent ventricular dilatation adversely affects the developing infant brain. Based on recent research, periventricular white matter injury is caused not only by ischemia and morphological distortion due to ventricular dilatation but also by free iron and inflammatory cytokines derived from hematoma and its lysates. The current guidelines for the treatment of posthemorrhagic hydrocephalus (PHH) in preterm infants do not provide strong recommendations, but initiating treatment intervention based on ultrasound measurement values before the appearance of clinical symptoms of PHH has been proposed. Moreover, in the past decade, therapeutic interventions that actively remove hematomas and lysates have been introduced. The era is moving beyond cerebrospinal fluid shunt toward therapeutic goals aimed at improving neurodevelopmental outcomes.
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