Evidence map›Paper›PMID 36858729›Full record

ReviewThe Lancet. Oncology2023

Harnessing imaging tools to guide immunotherapy trials: summary from the National Cancer Institute Cancer Imaging Steering Committee workshop.

Lalitha K Shankar, Heiko Schöder, Elad Sharon, Jedd Wolchok, Michael V Knopp, Richard L Wahl, Benjamin M Ellingson, Nathan C Hall, Martin J Yaffe, Alexander J Towbin and 13 more

Open access · greenAbstract readReview
In one paragraph

Review in The Lancet. Oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
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  4. Review
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  14. Review
  15. Prospective comparison ofFrontiers in oncology · 2024
    Article
  16. Advances in PET/CT Imaging for Breast Cancer.Journal of clinical medicine · 2023
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 17 institutions in 3 countries.

Lalitha K ShankarClinical Trials Branch, National Cancer Institute, Rockville, MD, USA. Electronic address: lalitha.shankar@nih.gov.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Elad SharonInvestigational Drug Branch, National Cancer Institute, Rockville, MD, USA.
Jedd WolchokMeyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Michael V KnoppDepartment of Radiology, Ohio State University, Columbus, OH, USA.
Richard L WahlDepartment of Radiology, Washington University, St Louis, MO, USA.
Benjamin M EllingsonDepartment of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA.
Nathan C HallDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Martin J YaffeMedical Biophysics, University of Toronto, Toronto, ON, Canada.
Alexander J TowbinDepartment of Radiology and Medical Imaging, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Michael D FarwellDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Daniel PrymaDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Tina Young PoussaintDepartment of Radiology, Boston Children's Hospital, Boston, MA, USA.
Chadwick L WrightDepartment of Radiology, Ohio State University, Columbus, OH, USA.
Lawrence SchwartzDepartment of Radiology, Columbia University, New York, NY, USA.
Mukesh HarisinghaniDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Umar MahmoodDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Anna M WuDepartment of Immunology & Theranostics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
David LeungBristol Myers Squibb, Princeton, NJ, USA.
Elisabeth G E de VriesDepartment of Medical Oncology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands.
Ying TangCCS Associates, McLean, VA, USA.
Gillian BeachThe Emmes Company, Rockville, MD, USA.
Steven A ReevesCoordinating Center for Clinical Trials, National Cancer Institute, Rockville, MD, USA.
National Cancer Institute · USUniversity of Pennsylvania · USMassachusetts General Hospital · USThe Ohio State University · USBoston Children's Hospital · USBristol-Myers Squibb (United States) · USCCS Associates (United States) · USCincinnati Children's Hospital Medical Center · USCity of Hope · USColumbia University · USEmmes (United States) · USMemorial Sloan Kettering Cancer Center · USUniversity Medical Center Groningen · NLUniversity of California, Los Angeles · USUniversity of Toronto · CAWashington University in St. Louis · USWeill Cornell Medicine · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
Cytotoxic lymphocyte function PET imaging to predict cancer immunotherapy responseR01CA214744 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MAHMOOD, UMAR · 2017 to 2021
$1.9M
Intramural NIH HHS Z99 CA999999NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA211015NCI NIH HHS R01 CA214744
6 · The paper itself

Abstract

As the immuno-oncology field continues the rapid growth witnessed over the past decade, optimising patient outcomes requires an evolution in the current response-assessment guidelines for phase 2 and 3 immunotherapy clinical trials and clinical care. Additionally, investigational tools-including image analysis of standard-of-care scans (such as CT, magnetic resonance, and PET) with analytics, such as radiomics, functional magnetic resonance agents, and novel molecular-imaging PET agents-offer promising advancements for assessment of immunotherapy. To document current challenges and opportunities and identify next steps in immunotherapy diagnostic imaging, the National Cancer Institute Clinical Imaging Steering Committee convened a meeting with diverse representation among imaging experts and oncologists to generate a comprehensive review of the state of the field.

Indexed as

NeoplasmsHumansImage Processing, Computer-AssistedImmunotherapyMedical OncologyNational Cancer Institute (U.S.)United States

Identifiers

PMID36858729
PMCPMC10119769
OpenAlexW4322422761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.