Observational studyGerontology2023
Multimorbidity and Functional Disability among Older Adults: The Role of Inflammation and Glycemic Status - An Observational Longitudinal Study.
Observational study in Gerontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 12 citations in OpenAlex.
- Association of N-butylphthalide treatment with 1-year activities-of-daily-living recovery in convalescent ischemic stroke patients with chronic disease burden: a post-marketing real-world non-randomized controlled study.Frontiers in medicine · 2026Trial
- Effect of Chronic Noncommunicable Diseases Multimorbidity on Functional Disability in Older Adults in Ireland: Evidence From the 2019 Irish Health Survey.Chronic diseases and translational medicine · 2026Article
- Physical function frailty trajectory before and after cardiovascular event among older adults in three multinational cohorts.BMC public health · 2026Article
- Identifying a fitness tool in early old-age to predict long-term risk of disability, severe disability, and mortality.GeroScience · 2026Article
- eHealth Literacy, self-management, and selected clinical and social correlates of nutrition-inflammation level among older adults with diabetes.BMC health services research · 2026Article
- Correlation of Waist Circumference-Mediated Glycosylated Hemoglobin Levels With New-Onset BADL Disability.Journal of diabetes research · 2026Article
- Multimorbidity in the Brazilian adult population: Protocol for a systematic review and meta-analysis of prevalence.PloS one · 2026Article
- Multimorbidity and its associations with physical function, fall risk, and hospitalization cost in adults with type 1 diabetes: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Exosome-Based Proteomic Profiling for Biomarker Discovery in Pediatric Fabry Disease: Insights into Early Diagnosis Monitoring.Biomedicines · 2025Article
- Study on the association between dietary patterns and cardiovascular metabolic comorbidities among adults.Journal of health, population, and nutrition · 2025Article
- Article
- Associations between the risk of LUTS/BPH and the number and class of chronic diseases among middle-aged and elder men.Scientific reports · 2025Article
- Trajectories of health conditions predict cardiovascular disease risk among middle-aged and older adults: a national cohort study.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
introductionSpecific multimorbidity combinations, in particular those including arthritis, stroke, and cognitive impairment, have been associated with high burden of activities of daily living (ADL)-instrumental activities of daily living (IADL) disability in older adults. The biologic underpinnings of these associations are still unclear.
methodsObservational longitudinal study using data from the Health and Retirement Study (N = 8,618, mean age = 74 years, 58% female, 25% non-white) and negative binomial regression models stratified by sex to evaluate the role of inflammatory and glycemic biomarkers (high-sensitivity C-reactive protein (hs-CRP) and HbA1c) in the association between specific multimorbidity combinations (grouped around one of eight index diseases: arthritis, cancer, cognitive impairment, diabetes, heart disease, hypertension, lung disease, and stroke; assessed between 2006 and 2014) and prospective ADL-IADL disability (2 years later, 2008-2016). Results were adjusted for sociodemographic characteristics, body mass index, number of coexisting diseases, and baseline ADL-IADL score.
resultsMultimorbidity combinations indexed by arthritis (IRR = 1.1, 95% CI = 1.01-1.20), diabetes (IRR = 1.19, 95% CI = 1.09-1.30), and cognitive impairment (IRR = 1.11, 95% CI = 1.01-1.23) among men and diabetes-indexed multimorbidity combinations (IRR = 1.07, 95% CI = 1.01-1.14) among women were associated with higher ADL-IADL scores at increasing levels of HbA1c. Across higher levels of hs-CRP, multimorbidity combinations indexed by arthritis (IRR = 1.06, 95% CI = 1.02-1.11), hypertension (IRR = 1.06, 95% CI = 1.02-1.11), heart disease (IRR = 1.06, 95% CI = 1.01-1.12), and lung disease (IRR = 1.14, 95% CI = 1.07-1.23) were associated with higher ADL-IADL scores among women, while there were no significant associations among men.
conclusionThe findings suggest potential for anti-inflammatory management among older women and optimal glycemic control among older men with these particular multimorbidity combinations as focus for therapeutic/preventive options for maintaining functional health.
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