Evidence map›Paper›PMID 36857833›Full record

SynthesisPsychoneuroendocrinology2023

Systematic review and meta-analysis of the effect of adverse childhood experiences (ACEs) on brain-derived neurotrophic factor (BDNF) levels.

Neha Vyas, Courtney E Wimberly, M Makenzie Beaman, Samantha J Kaplan, Line J H Rasmussen, Jasmin Wertz, Elizabeth J Gifford, Kyle M Walsh

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychoneuroendocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Adverse childhood experiences and psychopathology in adolescents from northern Chile: the moderating role of the attachment style.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Neha VyasDuke University, Trinity College of Arts and Sciences, Durham, NC, USA.
Courtney E WimberlyDuke University School of Medicine, Durham, NC, USA; Duke University Department of Neurosurgery, Durham, NC, USA.
M Makenzie BeamanDuke University School of Medicine, Durham, NC, USA; Duke Children's Health and Discovery Initiative, Durham, NC, USA.
Samantha J KaplanDuke University School of Medicine, Durham, NC, USA.
Line J H RasmussenDuke University Department of Psychology and Neuroscience, Durham, NC, USA; Department of Clinical Research, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark.
Jasmin WertzDuke University Department of Psychology and Neuroscience, Durham, NC, USA; University of Edinburgh, Department of Psychology, Edinburgh, UK.
Elizabeth J GiffordDuke Children's Health and Discovery Initiative, Durham, NC, USA; Duke University Sanford School of Public Policy, Center for Child and Family Policy, Durham, NC, USA.
Kyle M WalshDuke University School of Medicine, Durham, NC, USA; Duke University Department of Neurosurgery, Durham, NC, USA; Duke Children's Health and Discovery Initiative, Durham, NC, USA. Electronic address: Kyle.Walsh@Duke.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2M
Research Education Component CoreP30AG072958 · NIA · DUKE UNIVERSITY · PI Heather E. Whitson · 2021 to 2026
$24.1M
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
NIA NIH HHS P30 AG072958NIGMS NIH HHS T32 GM007171NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

There is continued interest in identifying dysregulated biomarkers that mediate associations between adverse childhood experiences (ACEs) and negative long-term health outcomes. However, little is known regarding how ACE exposure modulates neural biomarkers to influence poorer health outcomes in ACE-exposed children. To address this, we performed a systematic review and meta-analysis of the impact of ACE exposure on Brain Derived Neurotrophic Factor (BDNF) levels - a neural biomarker involved in childhood and adult neurogenesis and long-term memory formation. Twenty-two studies were selected for inclusion within the systematic review, ten of which were included in meta-analysis. Most included studies retrospectively assessed impacts of childhood maltreatment in clinical populations. Sample size, BDNF protein levels in ACE-exposed and unexposed subjects, and standard deviations were extracted from ten publications to estimate the BDNF ratio of means (ROM) across exposure categories. Overall, no significant difference was found in BDNF protein levels between ACE-exposed and unexposed groups (ROM: 1.08; 95 % CI: 0.93-1.26). Age at sampling, analyte type (e.g., sera, plasma, blood), and categories of ACE exposure contributed to high between-study heterogeneity, some of which was minimized in subset-based analyses. These results support continued investigation into the impact of ACE exposure on neural biomarkers and highlight the potential importance of analyte type and timing of sample collection on study results.

Indexed as

Adverse Childhood ExperiencesBrain-Derived Neurotrophic FactorAdultBiomarkersChildHumansRetrospective StudiesBiomarkersBrain-Derived Neurotrophic FactorAdverse childhood experiencesBiomarkersBrain-derived neurotrophic factorMeta-analysisSystematic review

Identifiers

PMID36857833
PMCPMC10073327

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.