ArticleArteriosclerosis, thrombosis, and vascular biology2023
Sex Differences in Vascular Response to Mental Stress and Adverse Cardiovascular Events Among Patients With Ischemic Heart Disease.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Heightened Risk of Myocardial Ischemia With Mental Stress Among Black Women Survivors of a Myocardial Infarction in Midlife.Journal of the American Heart Association · 2026Article
- Mental stress as a trigger of cardiovascular events: A narrative review.European journal of clinical investigation · 2026Review
- Blunted baroreflex-mediated sympathoinhibition and vasodilation to countdown before exercise in young women compared to men.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Serum cortisol and AdipoR2 rs12342 were involved in the correlation between stress and serum cholesterol in a gender-specific manner.Metabolic brain disease · 2025Article
- Lifestyle medicine pillars for women's heart health.American journal of preventive cardiology · 2025Article
- Real-life Psychological Experiences and Cardiac Autonomic Physiology among Survivors of a Myocardial Infarction in Midlife.Research square · 2025Article
- Psychosocial stress and cardiovascular disease.American journal of preventive cardiology · 2025Review
- Getting to the Heart of the Matter: Exploring the Intersection of Cardiovascular Disease, Sex and Race and How Exercise, and Gut Microbiota Influence these Relationships.Reviews in cardiovascular medicine · 2025Review
- Prevalence and Recognition of Cardiovascular Risk Factors in 308 Women Consulting Their GP for Any Reason.Women's health reports (New Rochelle, N.Y.) · 2025Article
- A Comprehensive Review of Clinical Studies Applying Flow-Mediated Dilation.Diagnostics (Basel, Switzerland) · 2024Review
- Stress and cardiovascular disease: an update.Nature reviews. Cardiology · 2024Review
- The predictive value of serum fibrinogen and platelet distribution width for long-term cardiac death in acute myocardial infarction patients.Journal of thoracic disease · 2024Article
- The Role of Psychosocial Stress on Cardiovascular Disease in Women: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2024Review
- Blunted brachial blood flow velocity response to acute mental stress in PTSD females.Physiological reports · 2024Article
- Heart-brain axis: Pushing the boundaries of cardiovascular molecular imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Review
- Psychological Health and Ischemic Heart Disease in Women: A Review of Current Evidence and Clinical Considerations across the Healthspan.Current atherosclerosis reports · 2024Review
- Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured Cells.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy.Frontiers in neuroscience · 2023Review
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMicrovascular measures of vascular dysfunction during acute mental stress may be important determinants of major adverse cardiovascular events (MACE), especially among younger and middle-aged women survivors of an acute myocardial infarction.
methodsIn the MIMS2 study (Myocardial Infarction and Mental Stress 2), individuals who had been hospitalized for a myocardial infarction in the past 8 months were prospectively followed for 5 years. MACE was defined as a composite index of cardiovascular death and first/recurring events for nonfatal myocardial infarction and hospitalizations for heart failure. Reactive hyperemia index and flow-mediated dilation were used to measure microvascular and endothelial function, respectively, before and 30 minutes after a public-speaking mental stress task. Survival models for recurrent events were used to examine the association between vascular response to stress (difference between poststress and resting values) and MACE. Reactive hyperemia index and flow-mediated dilation were standardized in analyses.
resultsOf 263 patients (the mean age was 51 years; range, 25-61), 48% were women, and 65% were Black. During a median follow-up of 4.3 years, 64 patients had 141 adverse cardiovascular events (first and repeated). Worse microvascular response to stress (for each SD decrease in the reactive hyperemia index) was associated with 50% greater risk of MACE (hazard ratio, 1.50 [95% CI, 1.05-2.13];
conclusionsPeripheral microvascular dysfunction with mental stress was associated with adverse events among women but not men. In contrast, endothelial dysfunction was similarly related to MACE among both men and women. These results suggest a female-specific mechanism linking psychological stress to adverse outcomes.
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