Evidence map›Paper›PMID 36857601›Full record

ArticleEndocrinology2023

Disruption of RNA Splicing Is an Important Contributor to Congenital Hypopituitarism and Other Human Genetic Diseases.

Sally A Camper, Cathy Smith, Jacob O Kitzman

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Sally A CamperDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109-5618, USA.ORCID 0000-0001-8556-3379
Cathy SmithDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109-5618, USA.ORCID 0000-0003-1518-9320
Jacob O KitzmanDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109-5618, USA.ORCID 0000-0002-6145-882X

Funding

Hypopituitarism: role of PROP1 and retinoic acid signaling in regulation of pituitary stem cell differentiationR01HD097096 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAMPER, SALLY A. · 2019 to 2023
$2.2M
Massively parallel experimental measurement of variant functional impactsR01GM129123 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KITZMAN, JACOB OTTO · 2018 to 2022
$2.1M
High Throughput Functional Assessment SHH Signaling Variants Identified in Patients with Craniofacial Defects and HypopituitarismR03DE031037 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAMPER, SALLY A., KITZMAN, JACOB OTTO · 2021 to 2022
$230k
NICHD NIH HHS R01 HD097096NIGMS NIH HHS R01 GM129123
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DwarfismHypopituitarismHumansRNA PrecursorsRNA SplicingTranscription Factor Pit-1Transcription FactorsPOU1F1 protein, humanRNA PrecursorsTranscription Factor Pit-1Transcription Factorsbranch-pointhypopituitarismPOU1F1splice enhancersplice repressor

Identifiers

PMID36857601
PMCPMC10282917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.