Evidence map›Paper›PMID 36857457›Full record

ArticleScience advances2023

Distinct roles for canonical and variant histone H3 lysine-36 in Polycomb silencing.

Harmony R Salzler, Vasudha Vandadi, Benjamin D McMichael, John C Brown, Sally A Boerma, Mary P Leatham-Jensen, Kirsten M Adams, Michael P Meers, Jeremy M Simon, Robert J Duronio and 2 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Article
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  9. Review
  10. Article
  11. Article
  12. Genes & development · 2024
    Article
  13. Set2 and H3K36 regulate thebioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Article
  16. Lysine-36 ofbioRxiv : the preprint server for biology · 2023
    Article
  17. Article
  18. Article
  19. Reduced histone gene copy number disruptsbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Harmony R SalzlerIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-1544-8700
Vasudha VandadiIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
Benjamin D McMichaelIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-9270-1570
John C BrownIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-6987-0173
Sally A BoermaDepartment of Biology, Carleton College, Northfield, MN, USA.ORCID 0000-0002-2764-1452
Mary P Leatham-JensenIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-6416-021X
Kirsten M AdamsDepartment of Biology, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-5997-3099
Michael P MeersIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-3438-3938
Jeremy M SimonDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0003-3906-1663
Robert J DuronioIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.
Daniel J McKayIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0001-8226-0604
A Gregory MateraIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC, USA.ORCID 0000-0002-6406-0630
University of North Carolina at Chapel Hill · USCarleton College · US

Funding

NRSA IN GENETICST32GM007092 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEKELSKY, JEFF J. · 1985 to 2019
$5.9M
Role of histone PTMs in epigenetic control of metazoan transcription and RNA processingR35GM136435 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI A. Gregory Matera · 2020 to 2026
$4.7M
Genetic and epigenetic mechanisms of developmental gene regulationR35GM128851 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Daniel J McKay · 2018 to 2026
$3.9M
Epigenetic Control of the Cell Cycle During Animal DevelopmentR35GM145258 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert J Duronio · 2022 to 2026
$2.3M
NIGMS NIH HHS R35 GM128851NIGMS NIH HHS R35 GM136435NIGMS NIH HHS R35 GM145258NIGMS NIH HHS T32 GM007092
6 · The paper itself

Abstract

Polycomb complexes regulate cell type-specific gene expression programs through heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is essential for this process. Perturbation of H3K36 is thought to interfere with H3K27me3. We show that mutants of

Indexed as

Drosophila ProteinsHistonesAnimalsChromatinDrosophilaLysinePolycomb-Group ProteinsChromatinDrosophila ProteinsHistonesLysinePolycomb-Group Proteins

Identifiers

PMID36857457
PMCPMC9977188
OpenAlexW4322754299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.