ArticleScience advances2023
A genetically encoded far-red fluorescent indicator for imaging synaptically released Zn
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed.
- Synaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injury.Science advances · 2026Article
- Redesign of Calmodulin for Genetically Encoded ZnChemical & biomedical imaging · 2026Article
- An emerging role for synaptic ZnPharmacology & therapeutics · 2026Review
- An Ultraresponsive Green Biosensor for Robust in Vivo Imaging of Synaptic Zinc Dynamics.ACS sensors · 2026Article
- ZIP-ZnT1 complexes mediate a local ZnCellular and molecular life sciences : CMLS · 2026Article
- hpGRISZ: a high-performance fluorescent biosensor for in vivo imaging of synaptic zinc dynamics.bioRxiv : the preprint server for biology · 2025Article
- An Enhanced Red Bioluminescent Indicator for Responsive Detection of Physiological Calcium Dynamics in Cells and Mice.ACS sensors · 2025Article
- 1000 fold Ultra-Photosensitized Fluorescent Protein Mimics Toward Photocatalytic Proximity Labeling and Proteomic Profiling Functions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Molecular Spies in Action: Genetically Encoded Fluorescent Biosensors Light up Cellular Signals.Chemical reviews · 2024Review
- On the genesis and unique functions of zinc neuromodulation.Journal of neurophysiology · 2024Review
- Far-Red Fluorescent Proteins: Tools for Advancing In Vivo Imaging.Biosensors · 2024Review
- Fluorescent Protein-Based Sensors for Detecting Essential Metal Ions across the Tree of Life.ACS sensors · 2024Review
- An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke.Journal of pharmaceutical analysis · 2024Article
- A fluorescence-based binding assay for proteins using the cell surface as a sensing platform.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Cochlear zinc signaling dysregulation is associated with noise-induced hearing loss, and zinc chelation enhances cochlear recovery.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Engineering and Characterization of 3-Aminotyrosine-Derived Red Fluorescent Variants of Circularly Permutated Green Fluorescent Protein.Biosensors · 2024Article
- NeMeHg, genetically encoded indicator for mercury ions based on mNeonGreen green fluorescent protein and merP protein fromFrontiers in bioengineering and biotechnology · 2024Article
- Mutant Flavin-Based Fluorescent Protein Sensors for Detecting Intracellular Zinc and Copper inACS sensors · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Tianchen WuDepartment of Molecular Physiology and Biological Physics, and Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0003-2129-6181
Manoj KumarDepartment of Otolaryngology, Pittsburgh Hearing Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5139-1425
Jing ZhangDepartment of Molecular Physiology and Biological Physics, and Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0003-1573-8916
Shengyu ZhaoDepartment of Molecular Physiology and Biological Physics, and Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-2501-8464
Mikhail DrobizhevDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717-384, USA.
Mason McCollumDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506, USA.ORCID 0000-0002-4251-5913
Charles T AndersonDepartment of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506, USA.ORCID 0000-0003-3353-0182
Ying WangDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA.ORCID 0000-0001-6370-4134
Antje PokornyDepartment of Chemistry and Biochemistry, University of North Carolina Wilmington, Wilmington, NC 28403, USA.ORCID 0000-0001-6675-9966
Xiaodong TianDepartment of Molecular Physiology and Biological Physics, and Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0001-9590-9943
Yiyu ZhangDepartment of Molecular Physiology and Biological Physics, and Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0001-8636-2827
Thanos TzounopoulosDepartment of Otolaryngology, Pittsburgh Hearing Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-4583-145X
Hui-Wang AiDepartment of Molecular Physiology and Biological Physics, and Center for Membrane and Cell Physiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-5664-3270
Funding
Cell-specific Synaptic Plasticity in the Auditory BrainstemR01DC007905 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TZOUNOPOULOS, THANOS · 2007 to 2021
$6.9MNext-Gen Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound ProcessingR01EB033172 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai, Thanos Tzounopoulos · 2022 to 2026
$3.3MThe effects of synaptically released zinc on neuronal processing and brain functionR35GM138023 · NIGMS · WEST VIRGINIA UNIVERSITY · PI CHARLES ANDERSON · 2020 to 2026
$3.2MSynaptic, Cellular and Circuit Mechanisms of Cortical Plasticity after Cochlear DamageR01DC019618 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TZOUNOPOULOS, THANOS · 2021 to 2025
$3.1MResearch Training Program in Behavioral and Biomedical SciencesT32GM132494 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Anne Courtney DeVries, Kevin T Larkin · 2019 to 2026
$2.8MResource for Multiphoton Characterization of Genetically-Encoded ProbesU24NS109107 · NINDS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Mikhail Drobizhev · 2018 to 2026
$2.2MRed and Far-Red Fluorescent Biosensors for Compartmentalized Redox SignalingR01GM129291 · NIGMS · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2018 to 2021
$2.1MAn Integrated Fluorescent Biosensor, Imaging, and Analysis Toolkit for Islet BiologicsR01DK122253 · NIDDK · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2020 to 2023
$1.6MFluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's DiseaseRF1AG077773 · NIA · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2022 to 2022
$1.6MNIA NIH HHS RF1 AG077773NIBIB NIH HHS R01 EB033172NIDCD NIH HHS R01 DC007905NIDCD NIH HHS R01 DC019618NIDDK NIH HHS R01 DK122253NIGMS NIH HHS R01 GM129291NIGMS NIH HHS R35 GM138023NIGMS NIH HHS T32 GM132494NINDS NIH HHS U24 NS109107
Abstract
Synaptic zinc ion (Zn
Indexed as
Auditory CortexAnimalsBrainCell MembraneColoring AgentsMammalsMiceZincColoring AgentsZinc
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.