ArticleCell reports2023
Limiting Mrs2-dependent mitochondrial Mg
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Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
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Who cites it
22 citing papers in PubMed, 24 citations in OpenAlex.
- Excessive EFHD1-dependent ER-mitochondrial contacts drive a maladaptive antiviral response in metabolic liver disease.The Journal of clinical investigation · 2026Article
- Prohibitin controls MRS2-Mediated mitochondrial MgCell reports · 2026Article
- The Role of Metal Ions in Mitochondria: From Energy Metabolism to Cell Destiny.Biological trace element research · 2026Review
- Structural and mutational insights define ERMA as the ER MgScience advances · 2026Article
- Magnesium as a Bioenergetic Checkpoint Linking Mitochondrial Function, Metabolic Disease, and Aging.Aging cell · 2026Review
- Dysregulation of the glycolysis-mitochondrial metabolism axis in osteoarthritis: mechanisms and therapeutic implications.Journal of orthopaedic translation · 2026Review
- Lactylation-mitochondria axis in chronic kidney disease: metabolic reprogramming, epigenetic dysregulation, and therapeutic potential.Molecular and cellular biochemistry · 2026Review
- Human lncRNAProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Diabetes-induced Multiorgan Damage: Can Magnesium Delay the process?Current nutrition reports · 2026Review
- An interpretable prediction model for non-invasive identification of the phlegm-dampness constitution based on machine learning.Frontiers in endocrinology · 2026Article
- Nutritional Influences on Brown and Beige Adipocyte: Unraveling the Molecular Mechanisms and Metabolic Implications.Food science & nutrition · 2025Review
- Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism.Nature structural & molecular biology · 2025Article
- Structure and function of the human mitochondrial MRS2 channel.Nature structural & molecular biology · 2025Article
- Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype.NPJ precision oncology · 2025Article
- High-throughput identification of calcium-regulated proteins across diverse proteomes.Cell reports · 2024Article
- Magnesium Ion: A New Switch in Tumor Treatment.Biomedicines · 2024Review
- Magnesium: A Defense Line to Mitigate Inflammation and Oxidative Stress in Adipose Tissue.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial CaMitochondrion · 2024Article
- ERMA (TMEM94) is a P-type ATPase transporter for MgMolecular cell · 2024Article
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Authors and funding
29 authors at 5 institutions in 2 countries.
Travis R MadarisDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Manigandan VenkatesanDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Soumya MaityDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Miriam C SteinDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Neelanjan VishnuDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Mridula K VenkateswaranDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
James G DavisDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19103, USA.
Karthik RamachandranDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Sukanthathulse UthayabalanDepartment of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada.
Cristel AllenDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Ayodeji OsideleDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Kristen StanleyDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Nicholas P BighamDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Terry M BakewellDepartment of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Melanie NarkunanDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Amy LeDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Varsha KaranamDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Kang LiDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Aum MhapankarDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Luke NortonDepartment of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Jean RossDepartment of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA.
M Imran AslamDepartment of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
W Brian ReevesDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Brij B SinghDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Jeffrey CaplanDepartment of Biological Sciences, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711, USA.
Justin J WilsonDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Peter B StathopulosDepartment of Physiology and Pharmacology, Western University, London, ON N6A 5C1, Canada.
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19103, USA. Electronic address: baur@pennmedicine.upenn.edu.
Muniswamy MadeshDepartment of Medicine, Center for Mitochondrial Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Medicine, Cardiology/Diabetes Divisions, University of Texas Health San Antonio, San Antonio, TX 78229, USA. Electronic address: muniswamy@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USBiotechnology Institute · USCornell University · USUniversity of Pennsylvania · USWestern University · CA
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3MTRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4MSpectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3MMagnesium flux compendium: Discover ligands, channels, and metabolic signalsR35GM145294 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MADESH MUNISWAMY · 2022 to 2026
$2.9MMechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLDR01DK135179 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Joseph A. Baur, MADESH MUNISWAMY · 2023 to 2026
$2.1MControl of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for AtherosclerosisR01HL142673 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ALEVRIADOU, BARBARA RITA, MUNISWAMY, MADESH · 2018 to 2021
$2.0MIndirect calorimetry cages equipped for glucose and blood pressure telemetryS10OD025098 · OD · UNIVERSITY OF PENNSYLVANIA · PI BAUR, JOSEPH A. · 2019 to 2019
$750kEssential Role for SPG7 in Mitochondrial Permeability Transition Pore Assembly and FunctionR01GM135760 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2020 to 2021
$613kNHLBI NIH HHS R01 HL142673NIA NIH HHS T32 AG021890NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK135179NIGMS NIH HHS R01 GM109882NIGMS NIH HHS R01 GM135760NIGMS NIH HHS R35 GM145294NIH HHS S10 OD025098
Abstract
The most abundant cellular divalent cations, Mg
Indexed as
Adipose Tissue, BrownEnergy MetabolismAdipose Tissue, WhiteAnimalsCation Transport ProteinsDietDiet, High-FatMiceMitochondriaMitochondrial ProteinsObesityThermogenesisCation Transport ProteinsMitochondrial ProteinsMrs2 protein, mouseadipose expansionadipose tissuecalcium channelcardiometabolic diseaseCP: Metabolismdiabetesenergy imbalanceHCChepatocytesHIF1livermagnesium channelMCUmetabolic diseasemetabolic syndromemitochondrial dysfunctionMrs2NAFLDobesityWestern dietwhole-body metabolism
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