Evidence map›Paper›PMID 36857017›Full record

ArticleJournal of neurovirology2023

Herpesviruses, polyomaviruses, parvoviruses, papillomaviruses, and anelloviruses in vestibular schwannoma.

Maria K Jauhiainen, Ushanandini Mohanraj, Martin Lehecka, Mika Niemelä, Timo P Hirvonen, Diogo Pratas, Maria F Perdomo, Maria Söderlund-Venermo, Antti A Mäkitie, Saku T Sinkkonen

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurovirology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Absence of DNA viruses in ameloblastomas.European journal of oral sciences · 2026
    Article
  2. DNA Virus Detection in Olfactory Neuroblastomas Using Targeted Enrichment NGS.Neuropathology : official journal of the Japanese Society of Neuropathology · 2026
    Article
  3. Extracellular vesicles in viral disease management.Current research in microbial sciences · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Presence of herpesviruses, parvoviruses, and polyomaviruses in sinonasal lymphoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Maria K JauhiainenDepartment of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, POB 263, 00029, Helsinki, Finland. maria.jauhiainen@hus.fi.ORCID 0000-0003-2310-039X
Ushanandini MohanrajDepartment of Virology, University of Helsinki, Helsinki, Finland.
Martin LeheckaDepartment of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Mika NiemeläDepartment of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Timo P HirvonenDepartment of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, POB 263, 00029, Helsinki, Finland.
Diogo PratasDepartment of Virology, University of Helsinki, Helsinki, Finland.
Maria F PerdomoDepartment of Virology, University of Helsinki, Helsinki, Finland.
Maria Söderlund-VenermoDepartment of Virology, University of Helsinki, Helsinki, Finland.
Antti A MäkitieDepartment of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, POB 263, 00029, Helsinki, Finland.
Saku T SinkkonenDepartment of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, POB 263, 00029, Helsinki, Finland.
University of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Etiology of vestibular schwannoma (VS) is unknown. Viruses can infect and reside in neural tissues for decades, and new viruses with unknown tumorigenic potential have been discovered. The presence of herpesvirus, polyomavirus, parvovirus, and anellovirus DNA was analyzed by quantitative PCR in 46 formalin-fixed paraffin-embedded VS samples. Five samples were analyzed by targeted next-generation sequencing. Viral DNA was detected altogether in 24/46 (52%) tumor samples, mostly representing anelloviruses (46%). Our findings show frequent persistence of anelloviruses, considered normal virome, in VS. None of the other viruses showed an extensive presence, thereby suggesting insignificant role in VS.

Indexed as

AnelloviridaeHerpesviridaeNeuroma, AcousticParvovirusPolyomavirusDNA, ViralHumansDNA, ViralAnellovirusHerpesvirusParvovirusPolyomavirusVestibular schwannomaViral etiology

Identifiers

PMID36857017
PMCPMC10185587
OpenAlexW4322719461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.