Trial reportSports medicine (Auckland, N.Z.)2023
Pre-sleep Protein Ingestion Increases Mitochondrial Protein Synthesis Rates During Overnight Recovery from Endurance Exercise: A Randomized Controlled Trial.
Trial report in Sports medicine (Auckland, N.Z.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Pooled it
- Efficacy of dietary supplements on sports performance outcomes: a systematic review of evidence in elite athletes.Frontiers in nutrition · 2025Pooled it
- Effects of exercise and diet in patients with incurable gastroesophageal cancer: the RADICES study.JNCI cancer spectrum · 2026Trial
- Casein Supplementation Timing and Exercise Performance in Soccer Players: Pre-Sleep vs. Post-Exercise Intake-A Randomized Controlled Trial.Nutrients · 2025Trial
- Ingestion of 20 g Whey or Canola Protein Does Not Further Increase Muscle Protein Synthesis Rates During Recovery From Resistance Exercise In Healthy, Young Females.The Journal of nutrition · 2025Trial
- Presleep vs. Daytime Consumption of Casein-Enriched Milk: Effects on Muscle Function and Metabolic Health After Sleeve Gastrectomy.Nutrients · 2025Trial
- Effects of pre-sleep protein supplementation on plasma markers of muscle damage and inflammatory cytokines resulting from sprint interval training in trained swimmers.Journal of the International Society of Sports Nutrition · 2023Trial
- Review
- Current Perspectives on Protein Supplementation in Athletes: General Guidance and Special Considerations for Diabetes-A Narrative Review.Nutrients · 2025Review
- Recovery for Professional and Elite Amateur Golfers: A Scoping Review of Evidence-Based Methods.Sports medicine (Auckland, N.Z.) · 2025Article
- Protein and Aging: Practicalities and Practice.Nutrients · 2025Review
- Protein Nutrition for Endurance Athletes: A Metabolic Focus on Promoting Recovery and Training Adaptation.Sports medicine (Auckland, N.Z.) · 2025Review
- The 4Rs Framework of Sports Nutrition: An Update with Recommendations to Evaluate Allostatic Load in Athletes.Life (Basel, Switzerland) · 2025Review
- Advances in Understanding the Interplay between Dietary Practices, Body Composition, and Sports Performance in Athletes.Nutrients · 2024Review
- Impacts of protein quantity and distribution on body composition.Frontiers in nutrition · 2024Review
- The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans.Cell reports. Medicine · 2023Article
- Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide.The Journal of nutrition · 2023Article
- Transcriptomic Analysis of Human Skeletal Muscle in Response to Aerobic Exercise and Protein Intake.Nutrients · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCasein protein ingestion prior to sleep has been shown to increase myofibrillar protein synthesis rates during overnight sleep. It remains to be assessed whether pre-sleep protein ingestion can also increase mitochondrial protein synthesis rates. Though it has been suggested that casein protein may be preferred as a pre-sleep protein source, no study has compared the impact of pre-sleep whey versus casein ingestion on overnight muscle protein synthesis rates.
objectiveWe aimed to assess the impact of casein and whey protein ingestion prior to sleep on mitochondrial and myofibrillar protein synthesis rates during overnight recovery from a bout of endurance-type exercise.
methodsThirty-six healthy young men performed a single bout of endurance-type exercise in the evening (19:45 h). Thirty minutes prior to sleep (23:30 h), participants ingested 45 g of casein protein, 45 g of whey protein, or a non-caloric placebo. Continuous intravenous L-[ring-
resultsPooled protein ingestion resulted in greater mitochondrial (0.087 ± 0.020 vs 0.067 ± 0.016%·h
conclusionsProtein ingestion prior to sleep increases both mitochondrial and myofibrillar protein synthesis rates during overnight recovery from exercise. The overnight muscle protein synthetic response to whey and casein protein does not differ. CLINICAL
trial registrationNTR7251 .
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.