Evidence map›Paper›PMID 36856970›Full record

ArticleJournal of assisted reproduction and genetics2023

Effect of basal serum testosterone level on the ovarian response and the cumulative live birth rate in infertile women undergoing in vitro fertilization.

Rebecca S F Wan, Jennifer K Y Ko, Sofie S F Yung, Ernest H Y Ng, Raymond H W Li

Open access · greenAbstract read
In one paragraph

Article in Journal of assisted reproduction and genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rebecca S F WanDepartment of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam Road, Hong Kong, China.ORCID http://orcid.org/0000-0003-1279-5878
Jennifer K Y KoDepartment of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam Road, Hong Kong, China.ORCID http://orcid.org/0000-0003-0475-0645
Sofie S F YungDepartment of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam Road, Hong Kong, China.ORCID http://orcid.org/0000-0002-8730-5055
Ernest H Y NgDepartment of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam Road, Hong Kong, China.ORCID http://orcid.org/0000-0002-7688-4557
Raymond H W LiDepartment of Obstetrics and Gynaecology, The University of Hong Kong, Pokfulam Road, Hong Kong, China. raymondli@hku.hk.ORCID http://orcid.org/0000-0002-7957-7798
University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effect of basal serum testosterone levels on the ovarian response and the cumulative live birth rate of infertile women undergoing in vitro fertilization (IVF).

methodsIt is a retrospective study in a university-affiliated assisted reproduction center in Hong Kong. Infertile women undergoing the first IVF cycle in the center between December 2012 and November 2016 with archived serum samples and available information on cumulative live birth were included for the analysis.

resultsA total of 1122 women were included for analysis. The median basal serum testosterone level was 0.53 (25-75th percentile: 0.40-0.67) nmol/L. Women with higher basal serum testosterone levels required a lower total dosage of gonadotrophin and a shorter duration of stimulation and had more oocytes retrieved. The cumulative live birth rates did not differ among women with serum testosterone levels in the four quartiles. Basal serum testosterone level was not a significant independent predictor of the cumulative live birth after adjusted for the women's age and number of normally fertilized oocytes in a binary logistic regression. The areas under the receiver operative characteristics (ROC) curves in predicting low or high ovarian response and the cumulative live birth were all below 0.6.

conclusionHigher basal serum testosterone levels were associated with a better ovarian response but had no effect on the cumulative live birth rate of infertile women undergoing IVF.

Indexed as

Infertility, FemaleBirth RateFemaleFertilization in VitroHumansLive BirthOvulation InductionPregnancyPregnancy RateRetrospective StudiesTestosteroneTestosteroneCumulative live birth rateIn vitro fertilizationOvarian responseTestosterone

Identifiers

PMID36856970
PMCPMC10224885
OpenAlexW4322719157

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.