ArticleBehavior genetics2023
Bias in Gene-by-Environment Interaction Effects with Sum Scores; An Application to Well-being Phenotypes.
Article in Behavior genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes.European journal of psychotraumatology · 2025Article
- Gene-environment interaction in ADHD traits: the role of school environment, personality, callousness-unemotional traits and satisfaction with life.European child & adolescent psychiatry · 2025Article
- Practical Implications of Sum Scores Being Psychometrics' Greatest Accomplishment.Psychometrika · 2024Article
- The Heritability of Psychopathology Symptoms in Early Adolescence: Moderation by Family Cultural Values in the ABCD Study.Behavior genetics · 2024Article
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3 authors.
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Abstract
In the current study, we investigated the influence of using skewed sum scores on estimated gene-by-environment interaction effects (GxE) for life satisfaction and happiness with perceived social support. To this end, we analyzed item-level data from a large adult twin sample (Ns between 3610 and 11,305) of the Netherlands Twin Register. Item response theory (IRT) models were incorporated in unmeasured (univariate) GxE models, and measured GxE models (with social support as moderator). We found that skewness introduced spurious GxE effects, with the largest effect for the most skewed variable (social support). Finally, in the IRT model for life satisfaction, but not for happiness, heritability estimates decreased with higher social support, while this was not observed when analyzing sum scores. Together, our results indicate that IRT can be used to address psychometric issues related to the use of sum scores, especially in the context of GxE, for complex traits like well-being.
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